Growth inhibition of oral bacteria related to denture stomatitis by anti-candidal chalcones
Article first published online: 12 MAR 2008
Australian Dental Journal
Volume 42, Issue 5, pages 343–346, October 1997
How to Cite
Sato, M., Tsuchiya, H., Akagiri, M., Takagi, N. and Iinuma, M. (1997), Growth inhibition of oral bacteria related to denture stomatitis by anti-candidal chalcones. Australian Dental Journal, 42: 343–346. doi: 10.1111/j.1834-7819.1997.tb00141.x
- Issue published online: 12 MAR 2008
- Article first published online: 12 MAR 2008
- Received for publication July 1994. Revised December 1994. Accepted January 1995.
- Oral bacteria;
- growth inhibition;
- anti-candidal chalcone;
- denture stomatitis
In the antimicrobial therapy of denture stomatitis, it is desirable to inhibit the growth of not only the primary causative organism, Candida albicans, but also other oral bacteria closely associated with the condition. Three synthetic anti-candidal chalcones were characterized and compared for their additional activity in inhibiting these causative bacteria. Among the tested chalcones, 2,4,2′-trihydroxy-5′-methylchalcone showed the highest activity for different Gram-positive bacteria. It inhibited the growth of streptococci, staphylococci and lactobacilli at 25.0–50.0 μg/mL which was lower than or comparable to its minimum inhibitory concentration for candida. It functioned with a bactericidal action and leaked 260 nm-absorbing substances from the streptococcal cells. The antimicrobial activity of 2,4,2′-trihydroxy-5′-methylchalcone against both primary and secondary causative agents suggests it could be useful as a potent therapeutic agent in denture stomatitis.