The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste: an in vitro study

Authors

  • Z Wang,

    1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
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  • T Jiang,

    1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
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  • S Sauro,

    1. Biomaterials, Biomimetics and Biophotonics Department, King’s College London Dental Institute, Guy’s Dental Hospital, London, United Kingdom.
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  • DH Pashley,

    1. Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, USA.
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  • M Toledano,

    1. Dental Materials, School of Dentistry, University of Granada, Colegio Máximo, Campus de Cartuja, Granada, Spain.
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  • R Osorio,

    1. Dental Materials, School of Dentistry, University of Granada, Colegio Máximo, Campus de Cartuja, Granada, Spain.
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  • S Liang,

    1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
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  • W Xing,

    1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
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  • Y Sa,

    1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
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  • Y Wang

    1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
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Dr Yining Wang
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST)
Key Laboratory of Oral Biomedicine Ministry of Education
School and Hospital of Stomatology
Wuhan University
237 Luoyu Road
Wuhan
China
Email: wang.yn@whu.edu.cn

Abstract

Background:  Dentine hypersensitivity occurs easily on exposed dentine. This study aimed to evaluate the effectiveness of a novel bioactive glass-containing toothpaste on dentine permeability and remineralization.

Methods:  Thirty dentine discs were divided into three groups of 10 specimens each. The groups corresponded to the following brushing treatments: no brush, distilled water, and bioactive glass-containing toothpaste (Novamin). The toothpaste was applied twice a day for 7 days. Dentine permeability was measured after ethylene-diamine-tetraacetic acid (EDTA) etching, initial application, 3-day application, 7-day application and citric acid challenge, respectively. The dentine morphology was investigated using scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy was performed to monitor the mineral variation on demineralized dentine. Qualitative information of elemental variation before and after treatments on completely demineralized dentine was detected by energy dispersive X-ray (EDX) analysis.

Results:  The bioactive glass-containing toothpaste significantly reduced dentine permeability after the 7-day treatment and showed, under SEM, excellent resistance to acid challenge compared to the other groups. ATR/FTIR and EDX revealed increased mineral content after treatment with Novamin.

Conclusions:  As the innovative bioactive glass-containing toothpaste occlude dentinal tubules and resist acid challenge, it may be useful for the treatment of dentine hypersensitivity and dentine remineralization.

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