SCIENTIFIC ARTICLE

The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste: an in vitro study

  1. Z Wang1,
  2. T Jiang1,
  3. S Sauro2,
  4. DH Pashley3,
  5. M Toledano4,
  6. R Osorio4,
  7. S Liang1,
  8. W Xing1,
  9. Y Sa1,
  10. Y Wang1

Article first published online: 13 OCT 2011

DOI: 10.1111/j.1834-7819.2011.01361.x

Issue

Australian Dental Journal

Australian Dental Journal

Volume 56, Issue 4, pages 372–381, December 2011

Additional Information

How to Cite

Wang, Z., Jiang, T., Sauro, S., Pashley, D., Toledano, M., Osorio, R., Liang, S., Xing, W., Sa, Y. and Wang, Y. (2011), The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste: an in vitro study. Australian Dental Journal, 56: 372–381. doi: 10.1111/j.1834-7819.2011.01361.x

Author Information

  1. 1

    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

  2. 2

    Biomaterials, Biomimetics and Biophotonics Department, King’s College London Dental Institute, Guy’s Dental Hospital, London, United Kingdom.

  3. 3

    Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, USA.

  4. 4

    Dental Materials, School of Dentistry, University of Granada, Colegio Máximo, Campus de Cartuja, Granada, Spain.

*Dr Yining Wang The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University 237 Luoyu Road Wuhan China Email: wang.yn@whu.edu.cn

Publication History

  1. Issue published online: 30 NOV 2011
  2. Article first published online: 13 OCT 2011
  3. (Accepted for publication 9 March 2011.)

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Keywords:

  • Bioactive glass;
  • dentine hypersensitivity;
  • toothpaste;
  • attenuated total reflection Fourier transformed infrared spectroscopy;
  • scanning electron microscopy;
  • energy dispersive X-ray

Abstract

Background:  Dentine hypersensitivity occurs easily on exposed dentine. This study aimed to evaluate the effectiveness of a novel bioactive glass-containing toothpaste on dentine permeability and remineralization.

Methods:  Thirty dentine discs were divided into three groups of 10 specimens each. The groups corresponded to the following brushing treatments: no brush, distilled water, and bioactive glass-containing toothpaste (Novamin). The toothpaste was applied twice a day for 7 days. Dentine permeability was measured after ethylene-diamine-tetraacetic acid (EDTA) etching, initial application, 3-day application, 7-day application and citric acid challenge, respectively. The dentine morphology was investigated using scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy was performed to monitor the mineral variation on demineralized dentine. Qualitative information of elemental variation before and after treatments on completely demineralized dentine was detected by energy dispersive X-ray (EDX) analysis.

Results:  The bioactive glass-containing toothpaste significantly reduced dentine permeability after the 7-day treatment and showed, under SEM, excellent resistance to acid challenge compared to the other groups. ATR/FTIR and EDX revealed increased mineral content after treatment with Novamin.

Conclusions:  As the innovative bioactive glass-containing toothpaste occlude dentinal tubules and resist acid challenge, it may be useful for the treatment of dentine hypersensitivity and dentine remineralization.

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