ADRF RESEARCH REPORT
Improved periodontal health and cardiovascular risk
Article first published online: 3 OCT 2011
© 2011 Australian Dental Association
Australian Dental Journal
Volume 56, Issue 4, pages 352–357, December 2011
How to Cite
Rose-Hill, S., Ford, P., Leishman, S., Do, H., Palmer, J., Heng, N., West, M., Seymour, G. and Cullinan, M. (2011), Improved periodontal health and cardiovascular risk. Australian Dental Journal, 56: 352–357. doi: 10.1111/j.1834-7819.2011.01363.x
- Issue published online: 30 NOV 2011
- Article first published online: 3 OCT 2011
- (Accepted for publication 30 March 2011.)
- Periodontal disease;
- cardiovascular disease;
- serum antibodies;
- Porphyromonas gingivalis;
- heat shock protein 60 (HSP60)
Background: Previous studies have demonstrated variable effects on systemic inflammatory and immune responses following improved periodontal health. This study examined changes in serum levels of the inflammatory mediators IL-1β, IL-6, TNF-α and sICAM-1, and antibodies to Porphyromonas gingivalis, human heat shock protein (hHSP) 60 and P. gingivalis GroEL following improvement in periodontal health in high cardiovascular (CV) risk and low CV-risk patients.
Methods: Patients retrospectively selected from a longitudinal study, had undergone yearly periodontal examinations and peripheral blood collections. They had demonstrated a quantifiable improvement in periodontal health (>60% reduction in number of sites with probing depth ≥4 mm from the baseline visit) and could be classified as either high CV-risk (≥6 classical risk factors, n = 13) or low CV-risk (≤1 classical risk factor, n = 14). Serum levels of the cytokines and antibodies were measured using ELISA.
Results: For sICAM-1 and anti-P. gingivalis GroEL and anti-hHSP60 antibodies, most patients recorded decreased levels. Reductions in serum sICAM-1 levels were more notable in low CV-risk patients (p = 0.006); and reductions in levels of anti-P. gingivalis GroEL and anti-hHSP60 antibodies (p = 0.001 and 0.009 respectively) were more notable in high CV-risk patients.
Conclusions: This study found that subsequent to improved periodontal health, the anti-HSP (HSP60 and GroEL) antibody response was reduced, particularly for high CV-risk patients. sICAM-1 levels were also lowered, more so for low CV-risk patients.