Leptospiral Uveitis – There Is More to It Than Meets the Eye!


Ashutosh Verma. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, MN 469 Chandler Medical Center, Lexington, KY 40536-0298, USA. Tel.: 1 859 257 9305; 1 859 257 9358; Fax: 1 859 257 8994; E-mail: ashutosh.verma@uky.edu


Leptospirosis, caused by pathogenic species of genus Leptospira, is a highly prevalent zoonotic disease throughout many parts of the world, and an important emerging disease within the United States. Uveitis is a common complication of systemic infection in humans. A similar condition in horses is characterized by recurrent bouts of inflammation. In this article, we review advances in our understanding of leptospiral uveitis and its pathogenic mechanisms.