This study was carried out to determine the current state of foot and mouth disease (FMD) in different animal species in Sharkia governorate in Egypt. In addition, we investigated the spreading of the virus through water and soil in the animal environment as well as by rodents. The isolation rates of FMD virus in tissue culture were 39.6%, 11.4%, 41.2% and 100% for cattle, buffalo, sheep and goat respectively. All animals did not show any clinical signs for FMD. In addition, the virus was isolated from the milk of an animal as well as from a water sample while all soil samples were negative.