Transient elastography for patients with chronic hepatitis B and C virus infection: Non-invasive, quantitative assessment of liver fibrosis

  1. Eiichi Ogawa1,
  2. Norihiro Furusyo1,2,*,
  3. Kazuhiro Toyoda2,
  4. Hiroaki Takeoka2,
  5. Shigeru Otaguro1,
  6. Maki Hamada1,
  7. Masayuki Murata1,
  8. Yasunori Sawayama1,
  9. Jun Hayashi1,2

Article first published online: 1 JUL 2007

DOI: 10.1111/j.1872-034X.2007.00160.x

Issue

Hepatology Research

Hepatology Research

Volume 37, Issue 12, pages 1002–1010, December 2007

Additional Information

How to Cite

Ogawa, E., Furusyo, N., Toyoda, K., Takeoka, H., Otaguro, S., Hamada, M., Murata, M., Sawayama, Y. and Hayashi, J. (2007), Transient elastography for patients with chronic hepatitis B and C virus infection: Non-invasive, quantitative assessment of liver fibrosis. Hepatology Research, 37: 1002–1010. doi: 10.1111/j.1872-034X.2007.00160.x

Author Information

  1. 1

    Department of General Medicine, Kyushu University Hospital, and

  2. 2

    Department of Environmental Medicine and Infectious Diseases, Kyushu University, Fukuoka, Japan

*Dr Norihiro Furusyo, Department of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan. Email: furusyo@genmedpr.med.kyushu-u.ac.jp

Publication History

  1. Issue published online: 21 JUL 2007
  2. Article first published online: 1 JUL 2007
  3. Received 5 March 2007; revision 23 April 2007; accepted 5 May 2007.

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Keywords:

  • hepatitis B virus;
  • hepatitis C virus;
  • liver fibrosis;
  • transient elastography

Aim/Methods:  The aim of the present study was to compare the diagnostic performance of transient elastography (FibroScan) with that of serum fibrosis markers and stages of hepatic fibrosis by biopsy in 68 patients with chronic hepatitis B virus (HBV) and in 161 patients with hepatitis C virus (HCV) infection.

Results:  The serum levels of hyaluronic acid (r = 0.601) and type IV collagen (r = 0.663) significantly positively associated with the FibroScan values (all P < 0.05). Classified by fibrosis stages, the median values of FibroScan were 3.5 kPa for F0, 6.4 kPa for F1, 9.5 kPa for F2, 11.4 kPa for F3, and 15.4 kPa forF4 in patients with chronic HBV infection, and were 6.3 kPa for F0, 6.7 kPa for F1, 9.1 kPa for F2, 13.7 kPa for F3, and 26.4 kPa for F4 in those with chronic HCV infection. The values were significantly correlated with fibrosis stage for both (HBV, r = 0.559, P = 0.0093, and HCV, r = 0.686, P < 0.0001).

Conclusion:  These results suggest that FibroScan is an efficient and simple method for evaluating liver fibrosis in patients with chronic infection, both for HBV and HCV.

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