Recent trend of clinical features in patients with hepatocellular carcinoma

Authors

  • Yuko Nagaoki,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Hideyuki Hyogo,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Hiroshi Aikata,

    Corresponding author
    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Mio Tanaka,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Noriaki Naeshiro,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Takashi Nakahara,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Yoji Honda,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Daisuke Miyaki,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Tomokazu Kawaoka,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Shintaro Takaki,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Akira Hiramatsu,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Koji Waki,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Michio Imamura,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Yoshiiku Kawakami,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Shoichi Takahashi,

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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  • Kazuaki Chayama

    1. Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Science, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan
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Dr Hiroshi Aikata, Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan. Email: aikata@hiroshima-u.ac.jp

Abstract

Aim:  In this study, we evaluated the clinical characteristics of hepatocellular carcinoma (HCC) because the etiology of HCC has been changing recently.

Methods:  Consecutive 1374 HCC patients at our institution from 1995 to 2009 were enrolled and clinical characteristics were investigated.

Results:  Seventeen percent and 67% of HCC were related to hepatitis B virus (HBV-HCC) and hepatitis C virus (HCV-HCC), respectively. Fifteen percent of that was negative for hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (HCVAb) (NBNC-HCC). HCV-HCC tended to decrease and NBNC-HCC tended to increase in recent years. Patients with NBNC-HCC and HCV-HCC were significantly older than those with HBV-HCC. The complication rates of diabetes mellitus (DM), heavy alcohol consumption, hypertension, and hyperlipidemia in NBNC-HCC were significantly higher than those in other groups. Furthermore, the platelet counts and body mass index in NBNC-HCC were significantly higher than those of other groups. Among 209 NBNC-HCC patients, 58 patients underwent hepatic resection in which 29%, 36%, and 35% of those were based on non-alcoholic steatohepatitis (NASH), heavy alcohol consumption, and unknown etiology, respectively. DM was prevalent especially in NASH and heavy alcohol consumption. Cirrhosis was detected in 65%, 81%, and 15% in NASH-HCC, heavy alcohol consumption-HCC, and unknown etiology, respectively.

Conclusions:  NBNC-HCC has gradually been increasing in recent years. The present study elucidated that the presence of NASH and metabolic syndrome were important risk factors for NBNC-HCC and suggests that these patients should receive surveillance for HCC development.

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