Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon-alpha-2b and ribavirin combination therapy
Article first published online: 1 MAY 2012
© 2012 The Japan Society of Hepatology
Volume 42, Issue 10, pages 966–973, October 2012
How to Cite
Nishimura, T., Yamaguchi, K., Hashimoto, H., Niimi, T., Yokomizo, C., Fujii, H., Minami, M., Sakamoto, M., Ohnish, N., Nagao, Y., Okita, M., Umemura, A., Shima, T., Okanoue, T. and Itoh, Y. (2012), Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon-alpha-2b and ribavirin combination therapy. Hepatology Research, 42: 966–973. doi: 10.1111/j.1872-034X.2012.01016.x
- Issue published online: 23 SEP 2012
- Article first published online: 1 MAY 2012
- Accepted manuscript online: 4 APR 2012 03:22PM EST
- Received 2 February 2012; revision 20 March 2012; accepted 27 March 2012.
- chronic hepatitis C;
- complete early virological response;
- genotype 1;
Aim: Little is known about the appropriate use of peginterferon-α-2b (PEG IFN-α-2b) or ribavirin (RBV) in genotype 1 chronic hepatitis C (CH-C) patients with complete early virological response (cEVR). Female patients, especially the older, are known to experience inferior treatment outcomes.
Method: A total of 150 CH-C patients with cEVR treated for 48 weeks (n = 104) or 52–64 weeks (n = 46) with PEG IFN-α-2b and RBV combination therapy were retrospectively analyzed to evaluate the benefits of extended treatment.
Results: In the 48-week group, patients without a sustained virological response (SVR) were more often female (P = 0.004) and had received a significantly lower total RBV dose (P = 0.003) than those with SVR. The SVR rate in these female patients was similar to males with hepatitis C virus (HCV) RNA negativity at treatment week 8 (P = 0.413); however, it was lower than that in males with HCV RNA negativity at treatment week 12 (P = 0.005). In the 52–64-week group, although the total RBV dose (mg/kg) after treatment week 48 was less in females than in males (P = 0.027), the SVR rate in females was equivalent to that in males (P = 0.604).
Conclusion: Genotype 1 CH-C patients treated with PEG IFN-α-2b and RBV combination therapy without SVR were more often female and had received a lower total RBV dose than males. The smaller SVR rate in female patients with cEVR compared to males may be overcome by extending treatment even if the RBV dose is lowered due to anemia.