Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: block-randomised trial
Article first published online: 13 OCT 2011
© 2011 FDI World Dental Federation
International Dental Journal
Volume 61, Issue 5, pages 274–280, October 2011
How to Cite
Seki, M., Karakama, F., Kawato, T., Tanaka, H., Saeki, Y. and Yamashita, Y. (2011), Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: block-randomised trial. International Dental Journal, 61: 274–280. doi: 10.1111/j.1875-595X.2011.00073.x
- Issue published online: 13 OCT 2011
- Article first published online: 13 OCT 2011
- Xylitol gum;
- mutans streptococci;
Objectives: To assess the influence of xylitol chewing gum consumption on mutans streptococci level of 3–4 years old Japanese preschoolers.
Methods: 248 participants were examined regarding caries-related factors at baseline and were followed up at 6, 9, and 12 months after the baseline: assessors were blinded, subjects were open labelled and blocked parallel randomised; 142 were selected to use xylitol gum for 3 months (from months 6 to 9) and 106 were controls.
Results: 161 participants were analysed (xylitol n = 76, control n = 85). Nineteen caries-related variables, including xylitol gum consumption, were analysed for any association with the main outcome, plaque mutans streptococci scores development within the intervention period, by logistic regression. Six showed statistically significant associations by univariate analysis (P < 0.05). However, only xylitol gum consumption remained a significant negative association (P < 0.05) by multiple analyses. Interestingly, over 10% xylitol group children experienced diarrhoea, which was larger than previous investigations.
Conclusion: Xylitol gum is effective in avoiding increased plaque mutans streptococci in young children.