Assistant Professor, Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA 70803–8422.
Ammonia Metabolism and the Urea Cycle: Function and Clinical Implications
Article first published online: 28 JUN 2008
© 1994 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 8, Issue 2, pages 73–78, March 1994
How to Cite
Dimski, D. S. (1994), Ammonia Metabolism and the Urea Cycle: Function and Clinical Implications. Journal of Veterinary Internal Medicine, 8: 73–78. doi: 10.1111/j.1939-1676.1994.tb03201.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Accepted November 24, 1992
Disposal of waste products accumulated during metabolic processes is integral to the health of any living organism. Disposal of excess nitrogen and ammonia is no exception. Although nitrogen is essential for growth and maintenance in animals, an excess of some nitrogenous compounds can quickly lead to toxicity and death. Because of the correlation between ammonia accumulation and clinical disease, it is important for veterinary clinicians to understand the physiological mechanisms used to dispose of nitrogen and ammonia. Therefore, the purposes of this article are to review ammonia metabolism, the urea cycle, and the clinical implications of urea cycle dysfunction in diseases of companion animals.