166 Greene Hall, Department ofPathobiology, Auburn University, Alabama 36849–5519.
Identification of an Intrinsic Platelet Function Defect in Spitz Dogs
Version of Record online: 28 JUN 2008
© 1994 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 8, Issue 2, pages 93–98, March 1994
How to Cite
Boudreaux, M. K., Crager, C., Dillon, A.R., Stanz, K. and Toivio-Kinnucan, M. (1994), Identification of an Intrinsic Platelet Function Defect in Spitz Dogs. Journal of Veterinary Internal Medicine, 8: 93–98. doi: 10.1111/j.1939-1676.1994.tb03204.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
- Accepted December 2, 1992
A recently identified intrinsic platelet function defect in 2 Spitz dogs is described. Both affected dogs had a history of chronic intermittent bleeding primarily from the nasal, oral, and gastrointestinal mucosa. Platelet aggregation in response to adenosine diphosphate (ADP), collagen, and platelet activating factor (PAF) was absent; however, platelet shape change did occur. Platelets aggregated in response to gamma thrombin, although a delayed onset and a reduced velocity of aggregation were present. Platelet 14C-serotonin release was diminished in response to collagen and PAF. Glycoprotein Illa was detected on the surface of platelets by flow cytometry. Platelets were morphologically normal under light and electron microscopy. Two male Spitz dogs, related to one of the affected dogs, did not have a bleeding diathesis. Collagen-induced platelet aggregation, however, was diminished in these 2 dogs. This platelet defect most closely resembles the defect described in Basset hounds.