• 1
    Das KM, Tashjihan RJ. Chronic mitral valve disease in the dog. Vet Med Small Anim Clin 1965;60:12091215.
  • 2
    Detweiler DK, Patterson DF. The prevalence and types of cardiovascular disease in dogs. Ann N Y Acad Sci 1965; 127:481516.
  • 3
    Taylor DH, Sittnikow L. The diagnosis of canine cardiac disease. J Small Anim Pract 1968;9:589595.
  • 4
    Whitney JC. Observation on the effect of age on the severity of heart valve lesions in the dog. J Small Anim Pract 1974; 15:511522.
  • 5
    Braunwald E. Heart Disease, 3rd ed. Philadelphia , PA Saunders; 1988:1041.
  • 6
    Drzewiecki GM, Wasicko MJ, Li J. Diastolic mechanics and the origin of the third heart sound. Ann Biomed Eng 1991; 19:651667.
  • 7
    Glower DD, Murrah RL, Olsen CO, et al. Mechanical correlates of the third heart sound. J Am Coll Cardiol 1992; 19:450457.
  • 8
    Ozawa Y., Smith D., Craige E. Origin of the third heart sound. Part 1: Studies in dogs. Circulation 1983;67: 393398.
  • 9
    Calvert CA. Heart murmurs. In: LorenzMD, CorneliusLM, eds. Small animal medical diagnosis. Philadelphia , PA Lippincott C; 1987:174190.
  • 10
    Gould L., Ettinger SJ, Lyon AF. Intensity of the first heart sound and arterial pulse in mitral insufficiency. Dis Chest 1968;53: 545549.
  • 11
    Barlow JB. Mitral regurgitation In: Perspectives on the mitral valve. Philadelphia , PA : Davis FA; 1987:pp 113131.
  • 12
    Haffajee CI. Chronic mitral regurgitation. In: DalenJE, AlpertJS, eds. Valvular Heart Disease, 2nd ed. Boston , MA : Little, Brown and Company; 1987:111150.
  • 13
    Darke PGG. Valvular incompetence in Cavalier King Charles spaniels. Vet Rec 1987; 120:365366.
  • 14
    Häggström J., Hansson K., Kvart C., et al. Chronic valvular disease in the cavalier King Charles spaniel in Sweden. Vet Rec 1992; 131:549553.
  • 15
    Häggström J., Hansson K., Karlberg BE, et al. Plasma concentration of atrial natriuretic peptide in relation to severity of mitral regurgitation in Cavalier King Charles spaniels. Am J Vet Res 1994;55:698703.
  • 16
    Ettinger SJ, Suter PF. Acquired valvular and endocardial heart disease. In: Canine Cardiology. Philadelphia , PA : Saunders; 1970:324325.
  • 17
    Gompf RE. The clinical approach to heart disease: history and physical examination. In: FoxPR, ed. Canine and feline cardiology. New York , NY : Churchill Livingstone Inc, 1988:2942.
  • 18
    Lombard CW, Spencer CP. Correlation of radiographic, echocardiographic and electrocardiographic signs of left heart enlargement in dogs with mitral regurgitation. Vet Rad 1985;26:8997.
  • 19
    Hansson K. Assessment of left atrial enlargement: Comparison between thoracic radiography, B-and M-mode echocardiography. Proceedings of the XIIESVC meeting, October 6, 1993, Berlin. ESVC, 1993, 2.
  • 20
    Suter PF, Lord PF. Thoracic Radiography, text atlas of thoracic diseases of the dog and cat. Wettswil , Switzerland : Selbstverlag PF Suter; 1984:pp 2443, 100–113, 480–497, 551–575.
  • 21
    Tei C., Shah PM, Cherian G., et al. The correlates of an abnormal first heart sound in mitral-valve-prolapse syndromes. N Engl J Med 1982;307:334339.
  • 22
    Weissler AM, Harris WS, Schoenfeld CD. Bedside technics for the evaluation of ventricular function in man. Am J Cardiol 1969;23:577583.
  • 23
    Feldtman HA. Families of lines: random effects in linear regression analysis. J Appl Physiol 1988;64:17211732.
  • 24
    Bland M. An introduction to medical statistics. Oxford , England : Oxford University Press; 1991:248251.
  • 25
    Pierpont OL, Talley RC. Pathophysiology of valvular heart disease. Arch Intern Med 1982; 142:9981001.
  • 26
    Whitney JC. Cardiovascular Pathology. J Small Anim Pract 1967;8:459465.
  • 27
    Yellin EL, Yoran C., Frater RW, et al. Dynamics of acute experimental mitral regurgitation. In: IonescuMI, CohnLH, eds. Mitral valve disease: diagnosis and treatment. London , England : Butterworths; 1985:1126.
  • 28
    Braunwald E., Welch GH, Sarnoff SJ. Hemodynamic effects of quantitatively varied experimental mitral regurgitation. Circ Res 1957;5:539545.
  • 29
    Shah PM, Kramer DH, Gramiak R. Influence of the timing of atrial systole on mitral valve closure and on the first heart sound in man. Am J Cardiol 1970; 35:231237.
  • 30
    Leech G., Brooks N., Green-Wilkinson A., et al. Mechanism of influence of PR interval on loudness of first heart sound. Br Heart J 1980;43:138142.
  • 31
    Genest J., Durand LG. Relationship of the left ventricular and apical first sounds to the left ventricular pressure gradient. Med Biol Eng Comput 1985;23:9598.
  • 32
    Durand LG, Langlois YE, Lanthier T., et al. Spectral analysis and acoustic transmission of mitral and aortic valve closure. Part 3: Effects of altering heart rate and P-R interval. Med Biol Eng Comput 1990;28: 431438.
  • 33
    Quinones MA, Gaasch WH, Alexander JK. Influences on acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man. Circulation 1976;53:293302.
  • 34
    Komamura K., Shannon RP, Ihara T., et al. Exhaustion of Frank-Starling mechanism in conscious dogs with heart failure. Am J Physiol 1993;265:H11191131.
  • 35
    Pipers FS, Bonagura JD, Hamlin RL, et al. Echocardiographic abnormalities of the mitral valve associated with left-side heart diseases in the dog. J Am Vet Med Assoc 1981;179:580586.
  • 36
    McDonald IG. Echocardiographic assessment of left ventricular function in mitral valve disease. Circulation 1976; 53:865871.
  • 37
    Kusokawa R., Bruce DW, Sakamoto T., et al. Hemodynamic determinants of the amplitude of the second heart sound. J Appl Physiol 1966;21:938946.
  • 38
    Stein PD, Sabbah HN, Khaja F., et al. Exploration of the cause of the low intensity aortic component of the second sound in nonhypotensive patients with poor ventricular performance. Circulation 1978;57:590593.
  • 39
    Caulfield WH, de Leon AC, Perloff JK, et al. The clinical significance of the fourth heart sound in aortic stenosis. Am J Cardiol 1971;28:179182.
  • 40
    Sabbah HN, Khaja F., Anbe DT, et al. The aortic closure sound in pure aortic insufficiency. Circulation 1977;56:859863.
  • 41
    Smith D., Craige E. Heart sounds: toward a consensus regarding their origin. Am J Noninvas Cardiol 1988; 2:169179.
  • 42
    Sabbah HN, Stein PD. Investigation of the theory of and mechanism of the second heart sound. Circ Res 1976; 39:874882.
  • 43
    Weissler AM, Harris WS, Schoenfeld CD. Systolic time intervals in heart failure in man. Circulation 1968;37:149159.
  • 44
    Lewis RP, Rittgers SE, Forester WF, et al. A critical review of the systolic time intervals. Circulation 1977;56:146158.
  • 45
    Weissler AM. Systolic time intervals. In: ChengTO, ed. International textbook of Cardiology. Elmsford, New York , NY : Pergamon Press, 1986:180193.
  • 46
    Brubakk O., Overskeid K. Systolic time intervals in acute myocardial infarction. Acta Med Scand 1977; 199:3340.
  • 47
    Held P., Lindberg B., Swedberg K. Audibility of an artificial third heart sound in relation to its frequency, amplitude, delay from the second heart sound and the experience of the observer. Am J Cardiol 1984; 53:11691172.
  • 48
    Sekiya M., Hamada M., Mukai M., et al. No influence of heart rate on early diastolic time intervals. Am J Noninvas Cardiol 1991;5:121124.
  • 49
    Aravanis C. Silent mitral insufficiency. Am Heart J 1965;70: 620626.