• 1
    Cowles W. Fatigue as a contributory cause of pneumonia. Boston Med Surg J 1918; 179:555.
  • 2
    Berk LS, Nieman DC, Youngberg WS, et al. The effect of long endurance running on natural killer cells in marathoners. Med Sci Sports Exerc 1990;22:207212.
  • 3
    Field CJ, Gougeon R., Marliss EB. Circulating mononuclear cell numbers and function during intense exercise and recovery. J Appl Physiol 1991;71:10891097.
  • 4
    Fitzgerald L. Exercise and the immune system. Immunol Today 1988;9:337339.
  • 5
    Keast D., Cameron K., Morton AR. Exercise and the Immune Response. Sports Med 1988;5:248267.
  • 6
    Nieman D., Johanssen L., Lee J., et al. Infectious episodes in runners before and after a road race. J Sports Med Phys Fitness 1989;29:289296.
  • 7
    Nieman D., Johanssen L., Lee J., et al. Infectious episodes in runners before and after the LA Marathon. J Sports Med Phys Fitness 1990; 30:316328.
  • 8
    Nieman DC, Nehlsen-Cannarella SL, Markoff PA, et al. The effects of moderate exercise training on natural killer cells and acute upper respiratory tract infections. Int J Sports Med 1990;11:467473.
  • 9
    Peters E., Bateman E. Ultramarathon running and upper respiratory tract infections. S Afr Med J 1983;64:582584.
  • 10
    Cannon JG. Exercise and resistance to infection. J Appl Physiol 1993;74:973981.
  • 11
    Ferry A., Picard F., Duvallet A., et al. Changes in blood leucocyte populations induced by acute maximal and chronic submaximal exercise. Eur J Appl Physiol 1990; 59:435442.
  • 12
    Kendall A., Hoffman-Goetz L., Houston M., et al. Exercise and blood lymphocyte subset responses: Intensity, duration, and subject fitness effects. J Appl Physiol 1990; 69:251260.
  • 13
    MacNeil B., Hoffman-Goetz L., Kendall A., et al. Lymphocyte proliferation responses after exercise in men: Fitness, intensity, and duration effects. J Appl Physiol 1991;70:179185.
  • 14
    Brahmi Z., Thomas JE, Park M., Dowdeswell JRG. The effect of acute exercise on natural killer-cell activity of trained and sedentary human subjects. J Clin Immunol 1985;5:321328.
  • 15
    Soppi E., Varjo P., Eskola J.L.A. Laitinen. Effect of strenuous physical stress on circulatory lymphocyte number and function before and after training. J Clin Lab Immunol 1982;8:4346.
  • 16
    Pedersen BK, Tvede N., Hansen FR, et al. Modulation of natural killer cell activity in peripheral blood by physical exercise. Scand J Immunol 1988;27:673678.
  • 17
    Nieman D., Henson D., Johnson R., et al. Effects of brief, heavy exertion on circulating lymphocyte subpopulations and proliferative response. Med Sci Sports Exerc 1992;24:13391345.
  • 18
    Papa S., Vitale M., Mazzotti G., et al. Impaired lymphocyte stimulation induced by long-term training. Immunol Lett 1989; 22: 2933.
  • 19
    McCarthy DA, Dale MM. The leucocytosis of exercise a review and model. Sports Med 1988;6:333363.
  • 20
    Rose RJ, Allen JR. Hematologic responses to exercise and training. Vet Clin North Am Equine Pract 1985; 1:461476.
  • 21
    Wong C., Smith S., Thong Y. et al: Effects of exercise stress on various immune functions in horses. Am J Vet Res 1992; 53: 14121417.
  • 22
    Bayly WM. The interpretation of clinicopathologic data from the equine athlete. Vet Clin North Am Equine Pract 1987;3:631647.
  • 23
    Gimenez M., Mohan-Kumar T., Humbert JC, et al. Leukocyte, lymphocyte and platelet response to dynamic exercise: Duration or intensity effect Eur J Appl Physiol 1986;55:465470.
  • 24
    ChurchDB, EvansDL, LewisDR, et al. The effect of exercise on plasma adrenocorticotrophin, cortisol and insulin in the horse and adaptations with training. In: GillespieJR, RobinsonNE, eds. Equine Exercise Physiology 2. Davis , CA : ICEEP; 1987:506515.
  • 25
    Snow DH, Ricketts SW, Mason DK. Haematological response to racing and training exercise in Thoroughbred horse, with particular reference to the leucocyte response. Eq Vet J 1983; 15:149154.
  • 26
    Carlson GP, Ocen PO, Harrold D. Clinicopathologic alterations in normal and exhausted endurance horses. Theriogenology 1976;6:93103.
  • 27
    Hines MT, Leroux Al. Schott HC, et al. Changes in lymphocyte subpopulations following prolonged exercise in horses. Proceedings of the 12th Annual Veterinary Medical Forum, San Francisco, CA, 1994; 1016.
  • 28
    Rose RJ, Hodgson DR. Haematological and plasma biochemical parameters in endurance horses during training. Equine Vet J 1982; 14:144148.
  • 29
    Blank SE, Lee EG, Johansson JO, et al. Regional changes in lymphocyte subpopulations in the mouse following acute exercise stress. Med Sci Sports Exerc 1993;25:680.
  • 30
    Muir AL, Cruz M., Martin BA, et al. Leukocyte kinetics in the human lung: role of exercise and catecholamines. J Appl Physiol 1984;57:711719.
  • 31
    Davis WC, Marusic S., Lewin HA, et al. The development and analysis of species specific and cross reactive monoclonal antibodies to leukocyte differentiation antigens and antigens of the major histocompatibility complex for use in the study of the immune system in cattle and other species. Vet Immunol Immunopathol 1987; 15:337376.
  • 32
    Deuster PA, Curiale AM, Cowan ML, et al. Exercise-induced changes in populations of peripheral blood mononuclear cells. Med Sci Sports Exerc 1988;20:276280.
  • 33
    Ricken K-H, Rieder T., Hauck G., et al. Changes in lymphocyte subpopulations after prolonged exercise. Int J Sports Med 1990; 11: 132135.
  • 34
    Fahey JL, Prince H., Weaver M., et al. Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders. Am J Med 1984; 76:95100.
  • 35
    Steel CM, Evans J., Smith MA. Physiological variation in circulating B cell: T cell ratio in man. Nature 1974;247:387389.
  • 36
    Oshida Y., Yamanouchi K., Hayamizu S., et al. Effect of acute physical exercise on lymphocyte subpopulations in trained and untrained subjects. Int J Sports Med 1988;9:137140.
  • 37
    Nehlsen-Cannarella SL, Nieman DC, Balk-Lamberton AJ, et al. The effect of moderate exercise training on immune response. Med Sci Sports Exerc 1991;23:6470.
  • 38
    Herberman RB, Ortaldo JR. Natural killer cells: Their role in defenses against disease. Science 1981;214:2430.
  • 39
    Kay NE. Natural killer cells. CRC Crit Rev Clin Lab Sci 1986;22:343359.
  • 40
    Whiteside TL, Herberman RB. The role of natural killer cells in human disease. Clin Immunol Immunopathol 1989;53:123.
  • 41
    MacKinnonLT, ChickTW, vanAsA., et al. Effects of prolonged intense exercise on natural killer cell number and function. In: DotsonCO, HumphreyJH, eds. Exercise physiology: current selected research. New York , NY : AMS Press; 1988:7789.
  • 42
    MacKinnonLT. Exercise and natural killer cells what is the relationship Sports Med 1989;7:141149.
  • 43
    Pedersen BK, Tvede N., Christensen LD, et al. Natural killer cell activity in peripheral blood of highly trained and untrained persons. Int J Sports Med 1989; 10:129131.
  • 44
    Harris DT, Camenisch TD, Jaso-Friedmann L., et al. Expression of an evolutionarily conserved function associated molecule on sheep, horse and cattle natural killer cells. Vet Immunol Immunopathol 1993; 38:273282.
  • 45
    Mackinnon LT. Exercise and innate immunity: Phagocytes, complement, and acute phase proteins. In Exercise and Immunology. Champaign , IL : Human Kinetics; 1992:4148.
  • 46
    Lewicki R., Tchorzewski H., Denys A., et al. Effect of physical exercise on some parameters of immunity in conditioned sportsmen. Int J Sports Med 1987; 8:309314.
  • 47
    Smith JA, Telford RD, Mason IB, et al. Exercise, training and neutrophil microbicidal activity. Int J Sports Med 1990; 11:179187.
  • 48
    Adamson EJ. Slocombe. The effects of strenuous exercise on alveolar macrophages and peripheral blood granulocytes measured by flow cytometry. Proceedings of the 4th International Conference on Equine Exercise Physiology, Queensland, Australia. 1994; 1.
  • 49
    Buschmann H., Baumann M. Alterations of cellular immune response during intensive training of event horses. Zentralbl Veteri-narmed 1991; 38:9094.
  • 50
    Bieger AT, Weiss M., Michne G., et al. Exercise-induced monocytosis and modulation of monocyte function. Int J Sports Med 1980; 1:3036.
  • 51
    Fehr HG, Lotzerich H., Michna H. The influence of physical exercise on peritoneal macrophage functions: Histochemical and phagocytic studies. Int J Sports Med 1987;9:7781.
  • 52
    Fehr HG, Lotzerich H., Michna H. Human macrophage function and physical exercise: Phagocytic and histochemical studies. Eur J Appl Physiol 1989;58:613617.
  • 53
    Ortega E., Collazos ME, Barriga C., et al. Stimulation of the phagocytic function in guinea pig peritoneal macrophages by physical activity stress. Eur J Appl Physiol 1992;64:323327.
  • 54
    Keadle T., Pourciau S., Melrose P., et al. Acute exercise stress modulates immune function in unfit horses. J Equine Vet Sci 1993; 13:226231.
  • 55
    Kurcz EV, Lawrence LM, Kelley KW, et al. The effect of intense exercise on the cell-mediated immune response of horses. J Eq Vet Sci 1988;8:237239.
  • 56
    Hoffman-Goetz L., Keir R., Thorne R., et al. Chronic exercise stress in mice depresses splenic T lymphocyte mitogenesis in vitro. Clin Exp Immunol 1986;66:551557.
  • 57
    Nieman DC, Miller AR, Henson DA, et al. Effects of high-vs moderate-intensity exercise on natural killer cell activity. Med Sci Sports Exerc 1993;25:11261134.
  • 58
    Simpson JR, Hoffman-Goetz L. Exercise stress and murine natural killer cell function. Proc Soc Exp Biol Med 1990; 190:129135.
  • 59
    Nieman DC, Henson DA, Gusewitch G., et al. Physical activity and immune function in elderly women. Med Sci Sports Exerc 1993;25:823831.
  • 60
    Ortaldo JR, Mason A., Overton R. Lymphokine-activated killer cells. Analysis of progenitors and effectors. J Exp Med 1986; 164:11931205.
  • 61
    Hormanski CD, Truax R., Pourciau SS, et al. Induction of lymphokine-activated killer cells of equine origin: Specificity for equine target cells. Vet Immunol Immunopathol 1992;32:2536.
  • 62
    Tvede N., Kappel M., Halkjaer-Kristensen J., et al. The effect of light, moderate and severe bicycle exercise on lymphocyte subsets, natural and lymphokine activated killer cells, lymphocyte proliferative response and interleukin 2 production. Int J Sports Med 1993; 14:275282.
  • 63
    Mackinnon LT, Chick TW, van As A., et al. Decreased secretory immunoglobulins following intense endurance exercise. Sports Train Med Rehabil 1989; 1:209218.
  • 64
    Nieman DC, Tan SA, Lee JW, et al. Complement and immunoglobulin levels in athletes and sedentary controls. Int J Sports Med 1989; 10:12128.
  • 65
    Nieman DC, Nehlsen-Cannarella SL. The effects of acute and chronic exercise on immunoglobulins. Sports Med 1991; 11:183201.
  • 66
    Hedfors E., Holm G., Ivansen M., et al. Physiological variation of blood lymphocyte reactivity: T-cell subsets, immunoglobulin production and mixed-lymphocyte reactivity. Clin Immunol Immunopathol 1983;27:914.
  • 67
    Liu YG, Wang SY. The enhancing effect of exercise on the production of antibody to Salmonella typhi in mice. Immunol Lett 198687; 14:117120.
  • 68
    Eskola J., Ruuskanen O., Soppi E., et al. Effect of sport stress on lymphocyte transformation and antibody formation. Clin Exp Immunol 1978;32:339345.
  • 69
    Verde TJ, Thomas SG, Moore RW, et al. Immune responses and increased training of the elite athlete. J Appl Physiol 1992; 73: 14941499.
  • 70
    Mackinnon LT, Ginn E., Seymour G. Comparison of the effects of exercise during training and competition on secretory IgA levels. Med Sci Sports Exerc 1990;22:S125 (abstr, suppl).
  • 71
    Mackinnon LT, Jenkins DG, Dwan K. Salivary immunoglobulin response to exercise of varying intensity. Med Sci Sports Exerc 1993;25:S102 (abstr, Suppl.).
  • 72
    Mackinnon LT, Ginn E., Seymour G. Temporal relationship between exercise-induced decrease in salivary IgA concentration and subsequent appearance of upper respiratory illness in elite athletes. Med Sci Sports Exerc 1991;23:S45 (abstr, Suppl.).
  • 73
    HustonL., BaylyW., LiggittH., et al. Alveolar macrophage function in Thoroughbreds after strenuous exercise. In: GillespieJR, RobinsonNE, eds. Equine Exercise Physiology 2. Davis , CA : ICEEP; 1987:243253.
  • 74
    Huston L. Effects of interval training on pulmonary mucosal defenses of Thoroughbreds. Masters Thesis, Washington State University, Pullman , WA : 1986.
  • 75
    Wong C., Thompson H., Thong Y. et al: Effect of strenuous exercise stress on chemiluminescence response of equine alveolar macrophages. Equine Vet J 1990;22:3335.
  • 76
    McKane SA, Rose RJ. Effects of exercise intensity and training on bronchoalveolar lavage cytology in Thoroughbred horses. Proceedings of the 4th International Conference in Equine Exercise Physiology, Queensland, Australia, 1994; 67.
  • 77
    McKane S., Canfield P., Rose R. Equine bronchoalveolar lavage cytology: Survey of Thoroughbred racehorses in training. Aust Vet J 1993; 70:401404.
  • 78
    Gabriel H., Schwarz L., Steffens G., et al. Immunoregulatory hormones, circulating leucocyte and lymphocyte subpopulations before and after endurance exercise of different intensities. Int J Sports Med 1992; 13:3593662.
  • 79
    GalboH., GollnickPD. Hormonal changes during and after exercise. In: MarconnetP., PoortmansJR, HermansenL., eds. Medicine and Sport Science. Vol. 17, Physiological Chemistry of Training and Detraining. New York , NY : Karger; 1984:97110.
  • 80
    Snow DH, MacKenzie G. The metabolic effects of maximal exercise in the horse and adaptations with training. Equine Vet J 1977;9:134140.
  • 81
    Snow D., Rose R. Hormonal changes associated with long distance exercise. Equine Vet J 1981; 13:195197.
  • 82
    Snow DH, Harris RC, MacDonald IA, et al. Effects of high-intensity exercise on plasma catecholamines in the Thoroughbred horse. Equine Vet J 1992;24:462467.
  • 83
    Reichlin S. Neuroendocrine-immune interactions. N Engl J Med 1993;329:12461242.
  • 84
    Weicker W., Werle E. Interaction between hormones and the immune system. Int J Sports Med 1991;12:S3037.
  • 85
    Cox WI, Holbrook NJ, Friedman H. Mechanism of glucocorticoid action on murine natural killer cell activity. J Natl Cancer Inst 1983;71:973981.
  • 86
    Holbrook NJ, Cox WI, Homer HC. Direct suppression of natural killer cell activity in human peripheral blood leukocyte cultures by glucocorticoids and its modulation by interferon. Cancer Res 1983;43:40194025.
  • 87
    Crary B., Borysenko M., Sutherland DC, et al. Decrease in mitogen responsiveness of mononuclear cells from peripheral blood after epinephrine administration in humans. J Immunol 1983; 130: 694697.
  • 88
    Kappel M., Tvede N., Galbo H., et al. Evidence that the effect of physical exercise on NK cell activity is mediated by epinephrine. J Appl Physiol 1991;70:25302534.
  • 89
    MacKinnon LT. Exercise and cytokines: Interleukins, interferon and tumor necrosis factor. In Exercise and Immunology. Champaign , IL : Human Kinetics Publishers; 1992:5968.
  • 90
    Espersen GT, Elbaek A., Ernst E., et al. Effect of physical exercise on cytokines and lymphocyte subpopulations in human peripheral blood. Acta Pathol Microbiol Immunol Scand 1990; 98:395400.
  • 91
    Lewicki R., Tchorzewski H., Majewska E., et al. Effect of maximal physical exercise on T lymphocyte subpopulations and on IL 1 and IL 2 production in vitro. Int J Sports Med 1988;9:114117.
  • 92
    Viti A., Muscettola M., Paulesu L., et al. Effect of exercise on plasma interferon levels. J Appl Physiol 1985;59:426428.
  • 93
    Woods JA, Davis JM. Exercise, monocyte/macrophage function and cancer. Med Sci Sports Exerc 1994;26:147157.
  • 94
    Evans WJ, Meredith CN, Cannon JG, et al. Metabolic changes following eccentric exercise in trained and untrained men. J Appl Physiol 1986;61:18641868.
  • 95
    Smith JA, Telford RD, Baker MS, et al. Cytokine immunoreactivity in plasma does not change after moderate endurance exercise. J Appl Physiol 1992;73:13961401.
  • 96
    Baker B., Gaffin SL, Wells MT, et al. Endotoxaemia in racehorses following exertion. J S Afr Vet Assoc 1988; 59:6366.
  • 97
    Bosenberg AT, Brock-Utne JG, Gaffin SL, et al. Strenuous exercise causes systemic endotoxemia. J Appl Physiol 1988;65:106108.
  • 98
    Sprenger H., Jacobs C., Nain M., et al. Enhanced release of cytokines, interleukin-2 receptors and neopterin after long distance running. Clin Immunol Immunopathol 1992;63:188195.
  • 99
    Fiatarone MA, Morley JE, Bloom ET, et al. Endogenous opioids and the exercise-induced augmentation of natural killer cell activity. J Lab Clin Med 1988; 112:544552.
  • 100
    Gatti G., Cavallo R., Sartori ML, et al. Cortisol at physiological concentrations and prostaglandin E2 are additive inhibitors of human natural killer cell activity. Immunopharmacology 1986; 11: 119128.
  • 101
    Pedersen BK, Tvede N., Christensen LD, et al. Indomethacin in vitro and in vivo abolishes post-exercise suppression of natural killer cell activity in peripheral blood. Int J Sports Med 1990; 11: 127131.
  • 102
    MacKinnon LT. Exercise and resistance to infectious illness. In Exercise and Immunology. Champaign , IL : Human Kinetics Publishers; 1992:18.
  • 103
    Fedde MR, Kuhlmann WD, Blecha F., Minocha HC. The effects of stress on susceptibility to respiratory disease. Proceedings of the 3rd Veterinary Respiratory Symposium, Rosemont, IL: 1983: 8184.
  • 104
    Bayly WM, Liggitt HD, Huston LJ, et al. Stress and its effect on equine pulmonary mucosal defenses. Proceedings of the American Association of Equine Practioners, 1986:253262.
  • 105
    Morley PS, Townsend HGG, Haines DM. Risk factors associated with upper respiratory disease during an outbreak of equine influenza. Proceedings of the 9th Annual Veterinary Medical Forum, New Orleans, LA, 1991; 871.
  • 106
    Cox W.: Examining the immunologic and hematopoietic properties of an immunostimulant. Vet Med 1988;4:424428.
  • 107
    Mulcahy G., Quinn PJ. A review of immunomodulators and their application in veterinary medicine. J Vet Pharm Therap 1986; 9:119139.
  • 108
    Vail CD, Nestved AJ, Rollins BJ, et al. Adjunct treatment of equine respiratory disease complex (ERDC) with the Propionibacterium acnes immunostimulant, EqStim. J Eq Vet Sci 1990; 10:399403.
  • 109
    Veil L., Renney D. Suspected adverse pulmonary reactions to Equimune IV in four horses. Proceedings of the 12 Veterinary Respiratory Symposium, Kennett Square, PA, 1993.
  • 110
    Kishino Y., Moriguchi S. Nutritional factors and cellular immune responses. Nutr Health 1992;8:133141.
  • 111
    Parry-Billings M., Budgett R., Koutedakis Y., et al. Plasma amino acid concentrations in the overtraining syndrome: Possible effects on the immune system. Med Sci Sports Exerc 1992;24:13531358.
  • 112
    Kreider R., Ratzlaff R., Bertun E., et al. Effects of amino acid and carnitine supplementation on immune status during and intercollegiate swim season. Med Sci Sports Exerc 1993;25:S123 (abstr, Suppl.).
  • 113
    Snow DH, Gash SP, Cornelius J. Oral administration of ascorbic acid to horses. Equine Vet J 1987; 19:520523.
  • 114
    ThaxtonJP, PardueSL. Ascorbic acid and physiological stress. In: WeggerFT, TagwerkerFJ, MoustgarrdJ., eds. Proceedings of the Workshop on Ascorbic Acid in Domestic Animals. Scandinavian Association of Agricultural Sciences and the Royal Danish Agricultural Society, 1984; 152161.
  • 115
    LaPerriereA., FletcherMA, AntoniMH, et al. Aerobic exercise training in an AIDS risk group. Int J Sports Med 1991; 12:S5357.
  • 116
    LaPerriere AR, Antoni MH, Schneiderman N., et al. Exercise intervention attenuates emotional distress and natural killer cell decrements following notification of positive serologic status for HIV-1. Biofeedback Self Regul 1990; 15:229242.
  • 117
    Soloman GF. Psychosocial factors, exercise, and immunity: Athletes, elderly persons, and AIDS patients. Int J Sports Med 1991; 12:S5052.
  • 118
    Mackinnon LT. Exercise and cancer. In: Exercise and Immunology. Champaign , IL : Human Kinetics Publishers; 1992:7781.
  • 119
    Albanes D., Blair A., Taylor PR. Physical activity and risk of cancer in the NHANES I population. Am J Public Health 1989; 79:744750.
  • 120
    MacNeil B., Hoffman-Goetz L. Chronic exercise enhances in vivo and in vitro cytotoxic mechanisms of natural immunity in mice. J Appl Physiol 1993;74:388395.
  • 121
    Woods JA, Davis JM, Mayer EP, et al. Exercise increases inflammatory macrophage antitumor cytotoxicity. J Appl Physiol 1993;75:879886.
  • 122
    Gillis S., Kozak R., Durante M., et al. Immunological studies of aging. J Clin Invest 1981; 67:937942.