Box 100126 HSC, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610–0126; e-mail: email@example.com.
Amlodipine: A Randomized, Blinded Clinical Trial in 9 Cats with Systemic Hypertension
Article first published online: 28 JUN 2008
© 1998 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 12, Issue 3, pages 157–162, May 1998
How to Cite
Snyder, P. S. (1998), Amlodipine: A Randomized, Blinded Clinical Trial in 9 Cats with Systemic Hypertension. Journal of Veterinary Internal Medicine, 12: 157–162. doi: 10.1111/j.1939-1676.1998.tb02111.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Accepted November 17, 1997
- Calcium channel blockers;
- Feline renal failure
The efficacy of amlodipine (AML) was tested in hypertensive cats in a placebo-controlled, randomized, blinded clinical trial. Five cats were randomized to receive 0.625 mg AML once daily and 4 cats to receive placebo (PLA) once daily. The average systolic blood pressure (SBP) recorded by the Doppler method on day 0 was 212 ± 21 mm Hg in the AML group and 216 ± 32 mm Hg in the PLA group. On day 7, the cats receiving AML had a significantly lower average daily SBP (160 ± 30 mm Hg) but SBP in the PLA group was unchanged (207 ± 31 mm Hg). On day 7, all cats receiving PLA and one cat receiving AML were crossed over to the other group because of inadequate response. Blood pressure did not decrease adequately in 3 cats by day 14 (7 days of PLA and 7 days AML) and the treatment code was broken. Each of these cats was subsequently administered 1.25 mg AML daily. Cats requiring 1.25 mg AML once daily (6.1 kg ± 0.7 kg) weighed significantly more than cats that responded to 0.625 mg AML once daily (4.1 ± 0.7 kg). The average daily SBP recorded in the 6 cats that completed the study was significantly lower after 16 weeks of treatment (152 ± 14 mm Hg) compared to day 0 (221 ± 24 mm Hg). Three cats were euthanized before completion of the study. All 3 cats were responders to AML on day 7. SBPs measured 24 hours after AML administration were similar to the average daily SBP, suggesting that AML effectively controlled SBP for a 24-hour period. AML was shown to be an effective once-daily antihypertensive agent when administered to cats at a dosage of 0.18 ± 0.03 mg/kg sid.