• Open Access

An Overview of Proteinase Inhibitors

Authors

  • Kristen Hibbetts,

    Corresponding author
    1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN.
      Section of Critical Care, Veterinary Hospital, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104–6010; e-mail: hibbetts@vet.upenn.edu.
    Search for more papers by this author
  • Brad Hines,

    1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN.
    Search for more papers by this author
  • David Williams

    1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN.
    Search for more papers by this author

Section of Critical Care, Veterinary Hospital, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104–6010; e-mail: hibbetts@vet.upenn.edu.

Abstract

Proteinase inhibitors are proteins in the body that regulate the catalytic activity of proteinases. They are important in a large variety of physiologic processes including coagulation, digestion, tumor metastasis and immunity. Proteinase inhibitors are categorized as either nonspecific proteinase inhibitors or class-specific proteinase inhibitors. Nonspecific proteinase inhibitors are comprised soley of the alpha macroglobulins, most notably alpha2-macroglobulin. Class-specific proteinase inhibitors are subcategorized as serine proteinase inhibitors, aspartic proteinase inhibitors, metalloproteinase inhibitors, and cysteine proteinase inhibitors. Each subcategory is made up of numerous inhibitors. As the roles of individual proteinase inhibitors are determined, the therapeutic use of natural and synthetic proteinase inhibitors is also being investigated. The purpose of this article is to review the history and classification of proteinase inhibitors and their relevance to veterinary medicine.

Ancillary