• Open Access

Platelet Aggregation and Adenosine Triphosphate Secretion in Dogs with Untreated Multicentric Lymphoma

Authors

  • Jennifer S. Thomas,

    Corresponding author
    1. Department of Veterinary Pathobiology (Thomas), and the Department of Small Animal Medicine and Surgery (Rogers), College of Veterinary Medicine, Texas A&M University, College Station, TX.
    Search for more papers by this author
  • Kenita S. Rogers

    1. Department of Veterinary Pathobiology (Thomas), and the Department of Small Animal Medicine and Surgery (Rogers), College of Veterinary Medicine, Texas A&M University, College Station, TX.
    Search for more papers by this author

Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843–4467; e-mail: jthomas@cvm.tamn.edu.

Abstract

Whole-blood platelet aggregation and adenosine triphosphate secretion were measured in 15 dogs with untreated multicentric lymphoma and 10 normal control dogs to determine if dogs with lymphoma have altered platelet function. Dogs with quantitative platelet disorders (ie, thrombocytopenia or thrombocytosis) or with clinical evidence of a bleeding disorder were excluded from the study. Platelets from affected dogs had significantly greater maximum aggregation than those from control dogs, suggesting that platelets from dogs with lymphoma are hyperactive. Platelet hyperactivity may play a role in the development of hemostatic disorders (eg, disseminated intravascular coagulation) or in tumor metastasis. Further investigation is needed to determine if modification of platelet function in patients with lymphoma affects disease progression or outcome.

Ancillary