Dr Sweeney is presently affiliated with the Mid-Atlantic Equine Medical Center, Ringoes, NJ.
Metastatic Melanoma in Horses
Article first published online: 28 JUN 2008
Journal of Veterinary Internal Medicine
Volume 16, Issue 4, pages 452–456, July 2002
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How to Cite
MacGillivray, K. C., Sweeney, R. W. and Piero, F. D. (2002), Metastatic Melanoma in Horses. Journal of Veterinary Internal Medicine, 16: 452–456. doi: 10.1111/j.1939-1676.2002.tb01264.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Revised December 11, 2001; Accepted January 7, 2002
- Dermal melanocytosis;
The clinical and pathologic findings are reviewed for 14 horses with metastatic melanoma. All were older gray horses, with an average age of 16 years. The most common sites of primary tumors were the ventral tail, perineum, and parotid salivary gland. Metastases were found in multiple locations and caused a variety of clinical syndromes. The most common sites for metastases were the lymph nodes, liver, spleen, skeletal muscle, lungs, and surrounding or within blood vessels throughout the body. Many of the horses had dermal melanomas for years (range 1–6 years) before succumbing to metastatic disease. Histologic characteristic of dermal masses was not predictive of malignancy in the majority of cases. Treatment consisting of surgical debulking and administration of cimetidine, an autogenous vaccine, or both was attempted in 4 horses with no effect on outcome.