• 1
    Allen AL, Doige CE, Fretz PB, Townsend HG. Hyperplasia of the thyroid gland and concurrent musculoskeletal deformities in western Canadian foals: Reexamination of a previously described syndrome. Can Vet J 1994;35:3138.
  • 2
    Irvine CHG, Evans MJ. Post-natal changes in total and free thy-roxine and triiodothyronine in foal serum. J Reprod Fertil 1975; 23(Suppl):709.
  • 3
    Irvine CHG. Hypothyroidism in the foal. Equine Vet J 1984; 16: 302306.
  • 4
    McLaughlin BG, Doige CE. Congenital musculoskeletal lesions and hyperplastic goiter in foals. Can Vet J 1982;23:164168.
  • 5
    McLaughlin BG, Doige CE, McLaughlin PS. Thyroid hormone levels in foals with congenital musculoskeletal lesions. Can Vet J 1986;27:264267.
  • 6
    Shaver JR, Fretz PB, Doige CE, et al. Skeletal manifestations of suspected hypothyroidism in two foals. J Equine Med Surg 1979;3:269275.
  • 7
    Vivrette SL, Reimers TJ, Krood L. Skeletal disease in a hypo-thyroid foal. Cornell Vet 1984;74:373386.
  • 8
    Held JP, Patton CS, Toal RL, et al. Work intolerance in a horse with thyroid carcinoma. J Am Vet Med Assoc 1985;187:10441045.
  • 9
    Hillyer MN, Taylor FGR. Cutaneous manifestations of suspected hypothyroidism in a horse. Equine Vet Educ 1992;4:116118.
  • 10
    Lowe JE, Baldwin BH, Foote RH, et al. Equine hypothyroidism: The long term effects of thyroidectomy on metabolism and growth in mares and stallions. Cornell Vet 1974;64:276295.
  • 11
    Stanley O, Hillidge CJ. Alopecia associated with hypothyroidism in a horse. Equine Vet J 1982;14:165167.
  • 12
    Waldron-Mease E. Hypothyroidism and myopathy in racing Thoroughbreds and Standardbreds. J Equine Med Surg 1979;3:124128.
  • 13
    Harris P, Marlin D, Gray J. Equine thyroid function tests: A preliminary investigation. Br Vet J 1992;148:7180.
  • 14
    Hood DM, Stephens KA. Physiopathology of equine laminitis. Compend Cont Educ Pract Vet 1981;3:S454459.
  • 15
    Hood DM. Thyroid function in horses affected with laminitis. Southwest Vet 1987;38:8591.
  • 16
    Mayhew IG, Ferguson HO. Clinical, clinicopathologic, and ep-idemiologic features of anhidrosis in central Florida Thoroughbred horses. J Vet Intern Med 1987;1:136141.
  • 17
    Beech J, Garcia M. Hormonal response to thyrotropin-releasing hormone in healthy horses and in horses with pituitary adenoma. Am J Vet Res 1985;46:19411943.
  • 18
    Chen CL, Riley AM. Serum thyroxine and triiodothyronine concentrations in neonatal foals and mature horses. Am J Vet Res 1981;42:14151417.
  • 19
    Chen CL, Li WI. Effect of thyrotropin releasing hormone (TRH) on serum levels of thyroid hormones in Thoroughbred mares. J Equine Vet Sci 1986;6:5861.
  • 20
    Held JP, Oliver JW. A sampling protocol for the thyrotropin-stimulating test in the horse. J Am Vet Med Assoc 1984;184:326327.
  • 21
    Lothrup CD, Nolan HL. Equine thyroid function assessment with the thyrotropin-releasing hormone response test. Am J Vet Res 1986;47:942944.
  • 22
    Messer NT, Johnson PJ, Refsal KR, et al. Effect of food deprivation on baseline iodothyronine and cortisol concentrations in healthy, adult horses. Am J Vet Res 1995;56:116121.
  • 23
    Messer NT, Ganjam VK, Nachreiner RF, et al. Effects of dexa-methasone administration on serum thyroid hormone concentrations in clinically normal horses. J Am Vet Med Assoc 1995;206:6366.
  • 24
    Morris DD, Garcia M. Thyroid-stimulating hormone: Response test in healthy horses, and effect of phenylbutazone on equine thyroid hormones. Am J Vet Res 1983;44:503507.
  • 25
    Morris DD, Garcia M. Effects of phenylbutazone and anabolic steroids on adrenal and thyroid gland function tests in healthy horses. Am J Vet Res 1985;46:359364.
  • 26
    Oliver JW, Held JP. Thyrotropin stimulation test—New perspective on value of monitoring triiodothyronine. J Am Vet Med Assoc 1985;187:931934.
  • 27
    Sojka JE, Johnson MA, Bottoms GD. Serum triiodothyronine, total thyroxine, and free thyroxine concentrations in horses. Am J Vet Res 1993;54:5255.
  • 28
    Duckett WM, Manning JP, Weston PG. Thyroid hormone periodicity in healthy, adult geldings. Equine Vet J 1989;21:123125.
  • 29
    Sticker LS, Thompson DL, Jr, Gentry LR. Pituitary hormone and insulin responses to infusion of amino acids and N-methyl-D, L-aspartate in horses. J Anim Sci 2001;79:735744.
  • 30
    Winer BJ. Statistical Principles in Experimental Design, 2nd ed. McGraw-Hill; 1971.
  • 31
    Glade MJ, Reimers TJ. Effects of dietary energy supply on serum thyroxine, triiodothyronine and insulin concentrations in young horses. J Endocrinol 1985; 104:9398.
  • 32
    Swinker AM, McCurley JR, Jordan ER, et al. Effects of dietary excesses on equine serum thyroid hormone levels. J Anim Sci 1989; 65(Suppl l):255256.
  • 33
    Christensen RA, Malinowski K, Massenzio AM, et al. Acute effects of short-term feed deprivation and refeeding on circulating concentrations of metabolites, insulin-like growth factor I, insulin-like growth factor binding proteins, somatotropin, and thyroid hormones in adult geldings. J Anim Sci 1997;75:13511358.
  • 34
    Shussler GC. Nonthyroid illness. In: IngbarSH, BravermanLE, eds. Werner's the Thyroid. Philadelphia , PA : JB Lippincott; 1986: 381400.
  • 35
    Ferguson DC. Update on diagnosis of canine hypothyroidism. Vet Clin North Am Small Anim Pract 1994;24:515539.
  • 36
    Re RN, Kourides IA, Ridgeway EC, et al. The effect of glu-cocorticoid administration on human pituitary secretion of thyrotropin and prolactin. J Clin Endocrinol Metab 1976;43:338346.
  • 37
    Kaptein EM, Robinson WJ, Grieb DA, et al. Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the low thyroxine state of acute medical illnesses. J Clin Invest 1982;69:526535.
  • 38
    Wartofsky L, Burman KD. Alterations in thyroid function in patients with systemic illness: The “euthyroid sick syndrome Endocr Rev 1982;2:164217.
  • 39
    Chopra IG, Hershman JM, Pardridge WM, et al. Thyroid function in non-thyroidal illnesses. Ann Intern Med 1983;98:946957.
  • 40
    Ferguson DC. The effect of nonthyroidal factors on thyroid function tests in the dog. Compend Cont Educ Pract Vet 1988; 10: 13651377.
  • 41
    Peterson ME, Gamble DA. Effect of nonthyroidal illness on serum thyroxine concentrations in cats: 494 cases (1988). J Am Vet Med Assoc 1990;197:12031208.
  • 42
    Mooney CT, Little CJL, Macrae AW. Effect of illness not associated with the thyroid gland on serum total and free thyroxine concentrations in cats. J Am Vet Med Assoc 1996;208:20042008.
  • 43
    Slag MF, Morley JE, Elson MK, et al. Hypothyroxinemia in critically ill patients as a predictor of high mortality. J Am Med Assoc 1981;245:4345.
  • 44
    Kaptein EM, Weiner JM, Robinson WJ, et al. Relationship of altered thyroid hormone indices to survival in nonthyroidal illnesses. Clin Endocrinol (Oxf) 1982;16:565574.
  • 45
    Kaptein EM, Grieb DA, Spencer CA, et al. Thyroxine metabolism in the low thyroxine state of critical nonthyroidal illnesses. J Clin Endocrinol Metab 1981;53:764771.
  • 46
    Woeber KA, Maddux BA. Thyroid hormone binding in nonthy-roid illness. Metabolism 1981;30:412416.
  • 47
    Oppenheimer JH, Schwartz HL, Mariash CN, et al. Evidence for a factor in the sera of patients with nonthyroidal diseases which inhibits iodothyronine binding by solid matrices, serum proteins, and rat hepatocytes. J Clin Endocrinol Metab 1982;54:619628.
  • 48
    Chopra IJ, Huang TS, Beredo A, et al. Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3,5,′-triiodothyronine in sera of patients with nonthyroidal illnesses. J Clin Endocrinol Metab 1985;60:666672.
  • 49
    Chopra IJ, Huang TS, Beredo A, et al. Serum thyroid hormone binding inhibitor in nonthyroidal illnesses. Metabolism 1986;35:152159.
  • 50
    Baue AE, Gunther B, Hartl W, et al. Altered hormonal activity in severely ill patients after injury or sepsis. Arch Surg 1984;119:11251132.
  • 51
    Heinen E, Hermann J, Konighausen T, et al. Secondary hypo-thyroidism in severe nonthyroidal illness Horm Metab Res 1981;13:284288.
  • 52
    Faber J, Kirkgaard C, Rasmussen B, et al. Pituitary-thyroid axis in critical illness. J Clin Endocrinol Metab 1987;65:315320.
  • 53
    Ridgway, EC. Modern concepts of primary thyroid gland failure. Clin Chem 1996;42:179182.
  • 54
    Quinlan WJ, Michaelson S. Homologous radioimmunoassay for canine thyrotropin: Response of normal and x-irradiated dogs to pro-pylthiouracil. Endocrinology 1981;108:937942.
  • 55
    Williams DA, Scott-Moncrieff C, Bruner J, et al. Validation of an immunoassay for canine thyroid-stimulating hormone and changes in serum concentration following induction of hypothyroidism in dogs. J Am Vet Med Assoc 1996;209:17301732.
  • 56
    Dixon RM, Graham PA, Mooney CT. Serum thyrotropin concentrations: A new diagnostic test for canine hypothyroidism. Vet Rec 1996;138:594595.
  • 57
    Peterson ME, Melian C, Nichols R. Measurement of serum total thyroxine, triiodothyronine, free thyroxine, and thyrotropin concentrations for diagnosis of hypothyroidism in dogs. J Am Vet Med Assoc 1997;211:13961402.
  • 58
    Ramsey IK, Evans H, Heritage ME. Thyroid-stimulating hormone and total thyroxine concentrations in euthyroid, sick euthyroid and hypothyroid dogs. J Small Anim Pract 1997;38:540545.
  • 59
    Scott-Moncrieff JC, Nelson RW, Bruner JM, Williams DA. Comparison of serum concentrations of thyroid-stimulating hormone in healthy dogs, hypothyroid dogs, and euthyroid dogs with concurrent disease. J Am Vet Med Assoc 1998;212:387391.
  • 60
    Thompson DL, Godke RA, Nett TM. Effects of melatonin and thyrotropin releasing hormone on mares during the nonbreeding season. J Anim Sci 1983;56:668677.
  • 61
    Thompson DL, Nett TM. Thyroid stimulating hormone and pro-lactin secretion after thyrotropin releasing hormone administration to mares: Dose response during anestrus in winter and during estrus in summer. Domest Anim Endocrinol 1984;1:263268.
  • 62
    Astwood EB. Thyroid and antithyroid drugs. In: GoodmanLS, GoodmanA, eds. The Pharmacological Basis of Therapeutics, 4th eds. MacMillan; 1970: 14661500.
  • 63
    El Sheikh M, McGregor AM. Antithyroid drugs: Their mechanism of action and clinical use. In: WeetmanAP, GrossmanA, eds. Pharmacotherapeutics of the Thyroid Gland. New York , NY : Springer-Verlag; 1997: 188206.
  • 64
    Achmadi J, Terashima Y. The effect of propylthiouracil-induced low thyroid function on secretion response and action of insulin in sheep. Domest Anim Endocrinol 1995;12:157166.
  • 65
    Brosvic GM, Risser JM, Mackay-Sim A, Doty RL. Odor detection performance in hypothyroid and euthyroid rats. Physiol Behav 1996;59:117121.
  • 66
    Chan WY, Ng TB. Effect of hypothyroidism induced by pro-pylthiouracil and thiourea on male and female reproductive systems of neonatal mice. J Exp Zool 1995;273:160169.
  • 67
    Cimmino M, Mion F, Goglia F, et al. Demonstration on in vivo metabolic effects of 3,5-di-iodothyronine. J Endocrinol 1996; 149:319325.
  • 68
    Elsasser TH, Rumsey TS, Norton SA. Relationships between the thyroid and somatotropic axes in steers. I: Effects of propylthiouracil-induced hypothyroidism on growth hormone, thyroid stimulating hormone and insulin-like growth factor I. Domest Anim Endocrinol 1992;9:261271.
  • 69
    Elsasser TH, Rumsey TS, Kahl S. Relationships between the thyroid and somatotropic axes in steers. II: Effects of thyroid status on plasma concentrations of insulin-like growth factor I (IGF-I) and the IGF-I response to growth hormone. Domest Anim Endocrinol 1993;10:7185.
  • 70
    Schlenker EH, Means R, Burbach JA. Naloxone stimulates oxygen consumption but not ventilation in hypothyroid hamsters. Physiol Behav 1994;56:635638.
  • 71
    Shuaib A, Ijaz S, Hemmings S, et al. Decreased glutamate release during hypothyroidism may contribute to protection in cerebral ischemia. Exp Neurol 1994;128:260265.
  • 72
    Vischer CM, Foreman JH, Constable PD, et al. Hemodynamic effects of thyroidectomy in sedentary horses. Am J Vet Res 1999;60:1421.