Hemoglobin Solutions and Tissue Oxygenation
Article first published online: 28 JUN 2008
© 2003 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 17, Issue 2, pages 127–135, March 2003
How to Cite
Muir, W. W. and Wellman, M. L. (2003), Hemoglobin Solutions and Tissue Oxygenation. Journal of Veterinary Internal Medicine, 17: 127–135. doi: 10.1111/j.1939-1676.2003.tb02423.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Revised February 22, 2001; Accepted April 8, 2002.
- Functional capillary density;
- Nitric oxide;
- Oxygen delivery;
Oxygen (O2) delivery to tissues plays an important role in determining microcirulatory autoregulatory responses. The balance between O2 delivery by whole blood and tissue O2 consumption likely has evolved based on regulatory processes designed to accommodate the encapsulation of hemoglobin (Hb) within red blood cells (RBCs). The hemodynamic, rheologic, and physical properties of blood, or an alternate O2-carrying solution, can have important consequences for O2 delivery to tissue. The development of acellular hemoglobin-based oxygen carriers (HBOC) requires reassessment of the O2 loading and unloading charactistics of Hb, the effects of altering the rheologic properties of blood, and the impact of these changes on microcirculatory autoregulation and tissue oxygenation. A variety of experimental and clinical studies have demonstrated beneficial effects of HBOCs. However, mechanisms responsible for HBOC-facilitated, O2-dependent autoregulatory changes in the microcirculation have not been completely elucidated.