DMV, MSc, DACVIM, DECVIM-ca, Department of Small Animal Medicine, Ghent University, Salisbury-laan 133, B-9820 Merelbeke, Belgium; E-mail: sylvie.daminet@rug. ac.be
Influence of Drugs on Thyroid Function in Dogs
Version of Record online: 28 JUN 2008
© 2003 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 17, Issue 4, pages 463–472, July 2003
How to Cite
Daminet, S. and Ferguson, D. C. (2003), Influence of Drugs on Thyroid Function in Dogs. Journal of Veterinary Internal Medicine, 17: 463–472. doi: 10.1111/j.1939-1676.2003.tb02467.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
- Revised July 12, 2002; Accepted September 30, 2002.
- Nonsteroidal anti-inflammatory drugs;
- Potassium bromide;
Several drugs can affect thyroid function test results in humans and eventually lead to an erroneous evaluation of thyroid function. These medications can alter the synthesis, secretion, transport, or metabolism of thyroid hormones. Some drugs also directly inhibit the hypothalamic-pituitary-thyroid axis. The effects of drugs on thyroid function in dogs have long been underestimated and have most likely contributed to the overdiagnosis of hypothyroidism in this species. This manuscript 1st reviews pertinent thyroid physiology followed by an overview of drugs for which the effects on canine thyroid function have been studied. The effects of glucocorticoids, propranolol, sulfonamides, phenobarbital, potassium bromide, and nonsteroidal anti-inflammatory agents (NSAIDs) on canine thyroid function are summarized here. Knowledge of the potential effect of these medications on thyroid function should contribute to a more reliable interpretation of thyroid function test results in dogs.