Steeve Giguere, DVM, PhD, DACVIM, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, P.O. Box 100136, 2016 SW 16th Avenue, Gainesville, FL 32610; E-mail: firstname.lastname@example.org
Cardiac Troponin I in Pastured and Race-Training Thoroughbred Horses
Article first published online: 28 JUN 2008
© 2003 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 17, Issue 4, pages 597–599, July 2003
How to Cite
Phillips, W., Giguere, S., Franklin, R. P., Hernandez, J., Adin, D. and Peloso, J. G. (2003), Cardiac Troponin I in Pastured and Race-Training Thoroughbred Horses. Journal of Veterinary Internal Medicine, 17: 597–599. doi: 10.1111/j.1939-1676.2003.tb02486.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Revised November 27, 2002; Accepted January 10, 2003.
Cardiac troponin I (cTnI), a myocardial polypeptide, is a highly sensitive and specific biomarker of myocardial injury in people and dogs. The structure of cTnI is highly conserved across species, and equine myocardium has high reactivity with human immunoassays. The purpose of this study was to describe cTnI concentrations in normal pastured and race-training Thoroughbred horses. Ten horses on pasture and 10 horses in race training were studied. Horses were considered normal on the basis of physical examination, training performance, electrocardiography (ECG), and echocardiography. Serum cTnI concentrations were determined with a colorimetric immunoassay. The assay has an analytical sensitivity of 0.04 ng/mL. Serum cTnI concentrations in race-training horses were not significantly different from those of pastured horses. When groups were combined, mean cTnI concentration (±SD) was 0.047 ± 0.085 ng/mL, and the median was 0 (range, 0-0.35 ng/mL). The 90th percentile for both groups combined was 0.11 ng/mL. This study establishes a preliminary reference range for serum cTnI in normal Thoroughbred horses. Key words: Cardiac disease; Cardiac markers; Creatine kinase; Myocarditis.