Effects of Trimethoprim-Sulfadiazine on Thyroid Function of Horses
Article first published online: 28 JUN 2008
© 2004 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 18, Issue 3, pages 370–373, May 2004
How to Cite
Rothschild, C. M., Hines, M. T., Breuhaus, B., Gay, J. and Sellon, D. C. (2004), Effects of Trimethoprim-Sulfadiazine on Thyroid Function of Horses. Journal of Veterinary Internal Medicine, 18: 370–373. doi: 10.1111/j.1939-1676.2004.tb02563.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Revised October 21, 2003; Accepted November 20, 2003.
- Thyroid-stimulating hormonel;
- Thyrotropin-releasing hormone
Trimethoprim-sulfadiazine was administered to horses in a randomized, placebo controlled study to determine the effects of potentiated sulfonamides on thyroid function in normal horses. The treatment group included eight horses that received trimethoprim-sulfadiazine mixed with molasses orally at 30 mg/kg once daily for eight weeks. The control group included 8 horses that received an oral placebo (flour mixed with molasses) once daily for the same period. Thyroid function was evaluated prior to initiation of treatment and after 8 weeks of treatment. Serum concentrations of total and free triiodothyronine (T3), total and free thyroxine (T4), and thyroid stimulating hormone (TSH) were determined at rest and after a thyrotropin-releasing hormone (TRH) stimulation test. There was no detectable difference between treatment and control groups.