Preliminary Studies of Serum Acute–Phase Protein Concentrations in Hematologic and Neoplastic Diseases of the Dog
Version of Record online: 28 JUN 2008
© 2005 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 19, Issue 6, pages 865–870, November 2005
How to Cite
Tecles, F., Spiranelli, E., Bonfanti, U., Cerón, J.J. and Paltrinieri, S. (2005), Preliminary Studies of Serum Acute–Phase Protein Concentrations in Hematologic and Neoplastic Diseases of the Dog. Journal of Veterinary Internal Medicine, 19: 865–870. doi: 10.1111/j.1939-1676.2005.tb02779.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
- Received January 31, 2005; Revised April 21, 2005 and May 18, 2005; Accepted June 21, 2005.
- phase proteins;
Serum concentrations of acute-phase proteins (APPs): haptoglobin (Hp), ceruloplasmin (Cp), serum amyloid A (SAA), and C-reactive protein (CRP) were determined in healthy dogs (n = 15) and dogs with different diseases grouped as acute inflammation (I, n = 12), hematologic neoplasias (HT, including leukemia and lymphoma, n = 16), nonhematologic neoplasias (NHT, including epithelial, mesenchymal, and mixed, n = 20), and autoimmune hemolytic anemia (AIHA, n = 8). SAA and CRP were analyzed using commercially available enzyme-linked immunosorbent assay (ELISA) kits, and Hp and Cp were measured using colorimetric methods, all previously validated for use in dogs. Increased concentrations of all APPs were observed in all groups of diseased dogs, but statistical significance only was observed with Hp (I, P < .001; HT, P < .05), Cp (I, P < .05; AIHA, P < .01), and CRP (I, P < .001; HT, P < .001; AIHA, CRP P <.05). High variability in individual APPs within each group of diseases was found with no significant differences between leukemia and lymphoma as well as among different types of neoplasia. The AIHA group had smaller increases in Hp, SAA, and CRP but higher concentrations of Cp. When follow-up of individual cases was possible, a decrease in APPs generally was found in cases with favorable outcome. The results of this study suggest that neoplasia and hematologic diseases such as AIHA should be considered as possible causes of mild increases in APPs in dogs. Measurement of APPs may be helpful to assess clinical evolution and monitor treatment of these processes.