Previously presented in part as an oral presentation at the 22nd Annual American College of Veterinary Internal Medicine Forum, Minneapolis, MN, June 9–12, 2004.
Antibiotic Sensitivity Profiles Do Not Reliably Distinguish Relapsing or Persisting Infections from Reinfections in Cats with Chronic Renal Failure and Multiple Diagnoses of Escherichia coli Urinary Tract Infection
Article first published online: 5 FEB 2008
© 2006 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 20, Issue 2, pages 245–249, March 2006
How to Cite
Freitag, T., Squires, R. A., Schmid, J., Elliott, J. and Rycroft, A. N. (2006), Antibiotic Sensitivity Profiles Do Not Reliably Distinguish Relapsing or Persisting Infections from Reinfections in Cats with Chronic Renal Failure and Multiple Diagnoses of Escherichia coli Urinary Tract Infection. Journal of Veterinary Internal Medicine, 20: 245–249. doi: 10.1111/j.1939-1676.2006.tb02853.x
- Issue published online: 5 FEB 2008
- Article first published online: 5 FEB 2008
- Accepted August 31, 2005.
- Antibiotic resistance;
- Antibiotic susceptibility;
- Persistent infection
Older cats with chronic renal failure (CRF) commonly develop urinary tract infections (UTI). Uropathogenic Escherichia coli (UPEC) is identified as the causal agent of UTI in most affected cats. Infections are often complicated, and UPEC infections may persist or recur in these cats. Antibiotic sensitivity profiles have been used to distinguish relapsing or persisting UTI from reinfection by different clones of the same species. However, the accuracy with which antibiograms discriminate different urinary E coli clones in cats is uncertain. We studied 17 cystocentesis-derived UPEC isolates collected from 5 cats with stable CRF and multiple diagnoses of UTI. UTIs were classified as relapses versus persistent infections or reinfections using antibiograms determined by Kirby-Bauer discs and Etests±. Subsequently, clonality of UPEC isolates was determined by pulsed-field gel electrophoresis (PFGE). A comparison of PFGE results with antibiograms indicated that antibiotic resistance patterns varied considerably within several individual E coli clones. Both antibiotic susceptibility tests differentiated between relapsing or persistent infections and reinfections with only 58% overall efficiency. Thus, antibiotic sensitivity profiles cannot be relied upon to distinguish between persisting or relapsing infections as compared to reinfections in cats with CRF and multiple diagnoses of E coli UTI.