Evaluation of Plasma C-Terminal Atrial Natriuretic Peptide in Healthy Cats and Cats with Heart Disease
Article first published online: 14 FEB 2008
Copyright © 2008 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 22, Issue 1, pages 135–139, January–February 2008
How to Cite
Hori, Y., Yamano, S., Iwanaga, K., Kano, T., Tanabe, M., Uechi, M., Kanai, K., Nakao, R., Hoshi, F. and Higuchi, S. (2008), Evaluation of Plasma C-Terminal Atrial Natriuretic Peptide in Healthy Cats and Cats with Heart Disease. Journal of Veterinary Internal Medicine, 22: 135–139. doi: 10.1111/j.1939-1676.2007.0007.x
- Issue published online: 14 FEB 2008
- Article first published online: 14 FEB 2008
- Submitted July 6, 2007; Revised September 6, 2007; Accepted September 24, 2007.
- C-terminal atrial natriuretic peptide;
- Left atrial pressure
Background: The clinical implications of evaluating C-terminal atrial natriuretic peptide (ANP) concentration in cats are still controversial.
Hypothesis: The objective of this study was to investigate the relationship between plasma C-terminal ANP concentration and left atrial pressure (LAP) in healthy cats with volume overload (study 1), and to compare plasma C-terminal ANP in normal cats and cats with cardiomyopathy (study 2).
Animals: Five healthy adult cats were used in study 1, and clinically healthy cats (n=8) and cats with cardiomyopathy (n=14) were used in study 2.
Methods: In study 1, cats were anesthetized and given acetated Ringer's solution (100 mL/kg/h for 60 minute) via the cephalic vein. Hemodynamic measurements and blood samples, collected from the jugular vein, were performed at 10-min intervals. In study 2, blood samples from normal cats and cats with cardiomyopathy were collected from the cephalic vein. The plasma C-terminal ANP concentration was determined by radioimmunoassay for human α-ANP.
Results: In study 1, volume overload significantly increased the C-terminal ANP concentration and LAP from baseline. The C-terminal ANP concentration was strongly correlated with the mean LAP. In study 2, age, E wave velocity, and the ratios of the left atrium to aorta were significantly higher in the cats with cardiomyopathy compared with the normal cats. The C-terminal ANP concentration was significantly higher in the cats with cardiomyopathy compared with the normal cats.
Conclusions and Clinical Importance: Our results suggest that the measurement of plasma C-terminal ANP in cats may provide additional information for the diagnosis of heart disease.