Preliminary results presented at the American College Veterinary Internal Medicine Louisville, USA 2006.
Survival Characteristics and Prognostic Variables of Dogs with Mitral Regurgitation Attributable to Myxomatous Valve Disease
Article first published online: 14 FEB 2008
Copyright © 2008 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 22, Issue 1, pages 120–128, January–February 2008
How to Cite
Borgarelli, M., Savarino, P., Crosara, S., Santilli, R. A., Chiavegato, D., Poggi, M., Bellino, C., La Rosa, G., Zanatta, R., Haggstrom, J. and Tarducci, A. (2008), Survival Characteristics and Prognostic Variables of Dogs with Mitral Regurgitation Attributable to Myxomatous Valve Disease. Journal of Veterinary Internal Medicine, 22: 120–128. doi: 10.1111/j.1939-1676.2007.0008.x
- Issue published online: 14 FEB 2008
- Article first published online: 14 FEB 2008
- Submitted May 2, 2007; Revised July 9, 2007; Accepted September 25, 2007.
- Heart failure;
- Myxomatous mitral valve disease;
- Volume overload
Background: There are few studies evaluating the natural history and prognostic variables in chronic mitral valve disease (CMVI) in a heterogeneous population of dogs.
Objectives: To estimate survival and prognostic value of clinical and echocardiographic variables in dogs with CMVI of varying severity. Five hundred and fifty-eight dogs belonging to 36 breeds were studied.
Methods: Dogs were included after clinical examination and echocardiography. Long-term outcome was assessed by telephone interview with the owner.
Results: The mean follow-up time was 22.7 ± 13.6 months, and the median survival time was 19.5 ± 13.2 months. In univariate analysis, age>8 years, syncope, HR>140 bpm, dyspnea, arrhythmias, class of heart failure (International Small Animal Cardiac Health Council), furosemide therapy, end-systolic volume-index (ESV-I)>30 mL/m2, left atrial to aortic root ratio (LA/Ao)>1.7, E wave transmitral peak velocity (Emax)>1.2 m/s, and bilateral mitral valve leaflet engagement were associated with survival time when all causes of death were included. For the cardiac-related deaths, all the previous variables except dyspnea and EDV-I>100 mL/m2 were significantly associated with survival time. Significant variables in multivariate analysis (all causes of death) were syncope, LA/Ao>1.7 m/s, and Emax>1.2 m/s. For cardiac-related death, the only significant variable was LA/Ao>1.7.
Conclusions and Clinical Importance: Mild CMVI is a relatively benign condition in dogs. However, some clinical variables can identify dogs at a higher risk of death; these variables might be useful to identify individuals that need more frequent monitoring or therapeutic intervention.