Efficacy and Toxicosis of VELCAP-C Treatment of Lymphoma in Cats
Article first published online: 14 FEB 2008
Copyright © 2008 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 22, Issue 1, pages 153–157, January–February 2008
How to Cite
Hadden, A.G., Cotter, S.M., Rand, W., Moore, A.S., Davis, R.M. and Morrissey, P. (2008), Efficacy and Toxicosis of VELCAP-C Treatment of Lymphoma in Cats. Journal of Veterinary Internal Medicine, 22: 153–157. doi: 10.1111/j.1939-1676.2007.0031.x
- Issue published online: 14 FEB 2008
- Article first published online: 14 FEB 2008
- Submitted December 14, 2006; Revised March 5, 2007; Accepted October 1, 2007.
- Lactate dehydrogenase;
Background: Lymphoma is the most common malignancy affecting cats. A protocol employing vincristine, l-asparaginase, cyclophosphamide, doxorubicin, and prednisone (VELCAP-S) is effective and well tolerated in dogs with lymphoma. A 24-week variation of this protocol (VELCAP-C) was developed for treatment of cats.
Hypothesis: That VELCAP-C will result in survival times for cats with lymphoma that are similar to those obtained when cats are treated with a protocol that includes fewer chemotherapy agents.
Animals: Sixty-one cats with lymphoma.
Methods: Retrospective study. Outcomes evaluated were response to VELCAP-C therapy, toxicosis, and survival time. The effect of signalment, staging, CBC, and serum chemistry profile and dosage on these outcomes was examined.
Results: Six cats (10%) completed the protocol with a median survival of 1189 days. Forty-three percent (23 of 61) of the cats achieved complete response (CR) with a median survival time of 62 days. Cats that required a dose reduction of any drug during induction were more likely to achieve CR. Weight loss and hepatomegaly at diagnosis were negatively associated with response to treatment. Increased lactate dehydrogenase (LDH) serum activity at the time of initial treatment correlated with decreased survival times.
Conclusions and Clinical Importance: This multi agent protocol did not provide improved survival over historical data using protocols with fewer agents. Serum LDH activity levels might provide useful prognostic information for cats with lymphoma.