Effect of Feline Interferon-Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
Version of Record online: 28 JUN 2008
Journal of Veterinary Internal Medicine
Volume 21, Issue 6, pages 1193–1197, November 2007
How to Cite
Ritz, S., Egberink, H. and Hartmann, K. (2007), Effect of Feline Interferon-Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis. Journal of Veterinary Internal Medicine, 21: 1193–1197. doi: 10.1111/j.1939-1676.2007.tb01937.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
- Revised March 5, 2007, April 15, 2007; Accepted May 18, 2007.
- Feline coronavirus (FCoV);
Background: There is no therapy with proven efficacy to treat cats with feline infectious peritonitis (FIP).
Hypothesis: Feline interferon-omega (FeIFN-ω) prolongs survival time and increases quality of life in cats with FIP.
Animals: Thirty-seven privately owned cats were subjects of this study.
Methods: The study was performed as a placebo-controlled double-blind trial. Feline infectious peritonitis was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either FeIFN-to or a placebo. All cats received adjunctive treatment with glucocorticoids and antibiotics and passive immunization with Feliserin.
Results: There was no statistically significant difference in the survival time of cats treated with FeIFN-ω versus placebo or in any other variable evaluated (with the exception of the lymphocyte count). The cats survived between 3 and 200 days (median, 9 days). There was only 1 long-term survivor (>3 months), and the cat was in the FeIFN-ω group.
Conclusion and Clinical Relevance: No effect of FeIFN-ω on survival time or quality of life could be demonstrated in this study.