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Keywords:

  • Colic;
  • Equine;
  • Kidney;
  • Liver;
  • Lung;
  • Microthrombosis

Background:In humans and experimental animals, disseminated intravascular coagulation (DIC) causes fibrin deposition in several organs, which eventually leads to ischemia and multiorgan failure.

Hypothesis:Horses who died or were euthanized for severe gastrointestinal disorders could have fibrin deposits in different tissues.

Animals:Tissue-organ samples collected during postmortem examinations on 66 colic horses with poor prognoses (eg, severe intestinal ischemia, enteritis, peritonitis), from 11 colic horses with good prognoses (eg, large-colon obstruction or displacement), and from 16 slaughter horses.

Methods:Tissue samples (kidney, lung, liver) were stained with hematoxylin and eosin, and phosphotungstic acid hematoxylin for a blinded histologic examination. A fibrin score (grades 0 to 4) was established for each tissue sample and for each horse.

Results:Fibrin deposits were found in tissue specimens of 11 of 27 of horses (40.7%) in the ischemic group, 8 of 21 in the enteritis group (38.1%), and 7 of 18 in the peritonitis group (39.0%), whereas none of the horses in the obstructive group (n = 11) and only 1 horse in the slaughter group (n = 16) had fibrin deposits in their tissues. In addition, the mean fibrin score values for the ischemic, enteritis, and peritonitis groups (1.3 ± 1.7, 1.1 ± 1.6, and 0.9 ± 1.3, respectively) were statistically higher than those for the obstructive and slaughter groups (0.0 ± 0.0 and 0.1 ± 0.5, respectively). The largest fibrin deposits were found in the lungs.

Conclusions and Clinical Importance: Horses with severe gastrointestinal disorders have fibrin deposits that are consistent with capillary microthrombosis, multiorgan failure, and DIC.