Neurology, Department of Clinical Veterinary Sciences, P.O. Box 57, 00014 University of Helsinki, Finland; e-mail: firstname.lastname@example.org.
Benign Familial Juvenile Epilepsy in Lagotto Romagnolo Dogs
Article first published online: 5 FEB 2008
© 2007 American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 21, Issue 3, pages 464–471, May 2007
How to Cite
Jokinen, T.S., Metsähonkala, L., Bergamasco, L., Viitmaa, R., Syrjä, P., Lohi, H., Snellman, M., Jeserevics, J. and Cizinauskas, S. (2007), Benign Familial Juvenile Epilepsy in Lagotto Romagnolo Dogs. Journal of Veterinary Internal Medicine, 21: 464–471. doi: 10.1111/j.1939-1676.2007.tb02991.x
- Issue published online: 5 FEB 2008
- Article first published online: 5 FEB 2008
- Revised September 8, 2006, October 22, 2006; Accepted November 21, 2006.
- Cerebellar pathology;
- Focal seizure;
- Idiopathic epilepsy;
Background:Idiopathic childhood epilepsies with benign outcomes are well recognized in human medicine, but are not reported in veterinary literature. We recognized such a neurologic syndrome in Lagotto Romagnolo dogs.
Animals: Twenty-five Lagotto Romagnolo puppies from 9 different litters examined because of simple or complex focal seizures and 3 adult Lagotto Romagnolo dogs exhibiting similar clinical signs were used.
Methods: Clinical and diagnostic evaluations of affected dogs were conducted, including electromyography, electroencephalography, and other testing.
Results: Seizures in puppies began at 5 to 9 weeks of age and usually resolved spontaneously by 8 to 13 weeks. Those with the most severe seizures also had signs of neurologic disease between these seizures, including generalized ataxia and hypermetria. There were no abnormalities in routine laboratory screenings of blood, urine, and cerebrospinal fluid. Electromyography, brainstem auditory-evoked potentials, and magnetic resonance imaging revealed no specific and consistent abnormalities. Fourteen of 16 (87.5%) affected puppies and 2 of 3 (67%) adult dogs revealed epileptiform activity in the electroencephalogram. Histopathologic examination in 1 puppy and 1 adult dog revealed lesions of Purkinje cell inclusions and vacuolation of their axons restricted to the cerebellum. Pedigree analysis suggests an autosomal recessive mode of inheritance.
Conclusions and Clinical Importance: This disorder, with simple or complex focal seizures and cerebellar lesions, represents a newly recognized epileptic syndrome in dogs.