Effect of Benazepril on Survival and Cardiac Events in Dogs with Asymptomatic Mitral Valve Disease: A Retrospective Study of 141 Cases
Article first published online: 8 MAY 2008
Copyright © 2008 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 22, Issue 4, pages 905–914, July–August 2008
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How to Cite
Pouchelon, J.-L., Jamet, N., Gouni, V., Tissier, R., Serres, F., Carlos Sampedrano, C., Castaignet, M., Lefebvre, H. P. and Chetboul, V. (2008), Effect of Benazepril on Survival and Cardiac Events in Dogs with Asymptomatic Mitral Valve Disease: A Retrospective Study of 141 Cases. Journal of Veterinary Internal Medicine, 22: 905–914. doi: 10.1111/j.1939-1676.2008.0105.x
- Issue published online: 4 JUL 2008
- Article first published online: 8 MAY 2008
- Submitted October 10, 2007; Revised January 14, 2008; Accepted February 22, 2008.
- Angiotensin-converting enzyme inhibitor;
Background: Angiotensin-converting enzyme inhibitors (ACEIs) improve quality of life and extend the life span of dogs with naturally acquired ISACHC class II-III congestive heart failure (CHF). However, their effects on asymptomatic heart disease remain controversial.
Hypothesis: Benazepril (BNZ), an ACEI, could have beneficial effects at the asymptomatic stage of degenerative mitral valve disease (MVD).
Animals: Dogs with ISACHC class Ia MVD and moderate-to-severe mitral regurgitation (MR) assessed by the color Doppler mapping technique at entry (Day 0) were retrospectively included.
Methods: Dogs were assigned to the treated group (BNZ group) if they received BNZ (and no other cardiac medication) from Day 0 or to the untreated group (UT group) if they did not receive any cardioactive treatment until occurrence of CHF.
Results: A total of 141 dogs were included in the study, 66 in the BNZ group (dosage: 0.30 ± 0.13 mg/kg) and 75 in the UT group. In the population (n = 93) including all breeds except Cavalier (CKC) and King Charles Spaniels (KC), median survival time to all causes of death in the BNZ group (n = 34, 3.3 years) was significantly longer than in the UT group (n = 59, 1.9 years) as was time to cardiac event (P < .05). Conversely, no effect of the BNZ treatment was observed in the CKC and KC population.
Conclusions and Clinical Relevance: BNZ had beneficial effects in asymptomatic dogs other than CKC and KC affected by MVD with moderate-to-severe MR. Breed distribution should be taken into account for interpretation of clinical trials performed in dogs with cardiac disease.