• Open Access

Concentrations of Acute-Phase Proteins in Dogs with Steroid Responsive Meningitis-Arteritis


  • This work was carried out at the Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.

  • The abstract was published in part in the proceedings of the ACVIM Annual meeting in Seattle 2007 and in the proceedings of the 19th Symposium of the ECVN, JVIM 2007, 21 (5), 1141.

Corresponding author: Andrea Bathen-Noethen, Bahnhofstrasse 9, D- 51789 Lindlar, Germany; e-mail: bathen@vetneuro.de, andreabathen@gmx.de.


Background: Measurement of concentrations of acute-phase proteins (APPs) is used as an aid in the diagnosis of a variety of diseases in animals.

Objective: To determine the concentration of APPs in dogs with steroid responsive meningitis-arteritis (SRMA) and other neurologic diseases.

Animals: One hundred and thirty-three dogs with neurologic diseases, 6 dogs with sepsis, and 8 healthy dogs were included in the study. Thirty-six dogs had SRMA (31 of which had monitoring), 14 dogs had other meningoencephalitides (ME), 32 had disk disease (IVDD/DLSS), 26 had tumors affecting the central nervous system (TCNS), and 25 had idiopathic epilepsy (IE).

Methods: Prospective, observational study: C-reactive protein (CRP), α2-macroglobulin (AMG), and albumin concentrations were determined in the serum or plasma. CRP was also measured in the cerebrospinal fluid.

Results: Serum CRP was significantly higher in dogs with SRMA (inline image= 142 μg/mL ± 75) and sepsis (inline image= 114 μg/mL ± 67) in comparison with dogs with other neurologic diseases (inline image= 2.3–21 μg/mL; P < .001). There was no significant difference detected in AMG between groups. Serum albumin concentration was significantly lower (P < .01) in dogs with SRMA (inline image= 3.2 g/dL ± 0.41) than in other groups (inline image= 3.6–3.9 g/dL). Serum CRP concentration of SRMA dogs correlated with alkaline phosphatase levels (r= 0.515, P= .003).

Conclusions and Clinical Importance: CRP concentrations in serum are useful in diagnosis of dogs with SRMA. Serum CRP could be used as a monitoring parameter in treatment management of these dogs.