This study was presented as an abstract at the 17th ECVIM-CA Congress, Budapest, Hungary, September 13–15, 2007.
Remission of Diabetes Mellitus in Cats with Diabetic Ketoacidosis
Article first published online: 6 OCT 2008
Copyright © 2008 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 22, Issue 6, pages 1326–1332, November–December 2008
How to Cite
Sieber-Ruckstuhl, N.S., Kley, S., Tschuor, F., Zini, E., Ohlerth, S., Boretti, F.S. and Reusch, C.E. (2008), Remission of Diabetes Mellitus in Cats with Diabetic Ketoacidosis. Journal of Veterinary Internal Medicine, 22: 1326–1332. doi: 10.1111/j.1939-1676.2008.0201.x
- Issue published online: 30 OCT 2008
- Article first published online: 6 OCT 2008
- Submitted April 4, 2008; Revised June 20, 2008; Accepted August 26, 2008.
- Diabetic ketoacidosis;
- Remission of disease
Background: Diabetic ketoacidosis (DKA) has long been considered a key clinical feature of type-1 diabetes mellitus (DM) in humans although. An increasing number of cases of ketoacidosis have been reported in people with type-2 DM.
Hypothesis/Objectives: Cats initially diagnosed with DKA can achieve remission from diabetes. Cats with DKA and diabetic remission are more likely to have been administered glucocorticoids before diagnosis.
Animals: Twelve cats with DKA and 7 cats with uncomplicated DM.
Methods: Retrospective case review. Medical records of cats presenting with DKA or DM were evaluated. Diabetic remission was defined as being clinically unremarkable for at least 1 month after insulin withdrawal. The cats were assigned to 1 of 3 groups: (1) cats with DKA and diabetic remission; (2) cats with DKA without diabetic remission; and (3) cats with DM and diabetic remission.
Results: Seven cats with DKA had remission from diabetes. These cats had significantly higher concentrations of leukocytes and segmented neutrophils, and significantly lower concentrations of eosinophils in blood and had pancreatic disease more often than did cats with uncomplicated DM and diabetic remission. With regard to pretreatment, 3/7 cats in group 1, 1/5 cats in group 2, and 1/7 cats in group 3 had been treated with glucocorticoids.
Conclusions and Clinical Importance: Remission of DM in cats presenting with DKA is possible. Cats with DKA and remission have more components of a stress leucogram, pancreatic disease, and seemed to be treated more often with glucocorticoids than cats with uncomplicated DM and diabetic remission.