Retinol-Binding Protein in Serum and Urine of Hyperthyroid Cats before and after Treatment with Radioiodine

  1. I. Van Hoek1,5,
  2. E. Meyer2,
  3. L. Duchateau3,
  4. K. Peremans4,
  5. P. Smets1,
  6. S. Daminet1

Article first published online: 11 AUG 2009

DOI: 10.1111/j.1939-1676.2009.0364.x

Issue

Journal of Veterinary Internal Medicine

Journal of Veterinary Internal Medicine

Volume 23, Issue 5, pages 1031–1037, September/October 2009

Additional Information

How to Cite

Van Hoek, I., Meyer, E., Duchateau, L., Peremans, K., Smets, P. and Daminet, S. (2009), Retinol-Binding Protein in Serum and Urine of Hyperthyroid Cats before and after Treatment with Radioiodine. Journal of Veterinary Internal Medicine, 23: 1031–1037. doi: 10.1111/j.1939-1676.2009.0364.x

Author Information

  1. 1

    Department of Medicine & Clinical Biology of Small Animals, Ghent University, Merelbeke, Belgium

  2. 2

    Department of Pharmacology, Toxicology, Biochemistry and Organ Physiology, Ghent University, Merelbeke, Belgium

  3. 3

    Department of Physiology and Biometrics, Ghent University, Merelbeke, Belgium

  4. 4

    Department of Medical Imaging of Domestic Animals, Ghent University, Merelbeke, Belgium

  5. 5

    Royal Canin S.A., Centre de Recherche, Aimargues, France.

*Corresponding author: Ingrid van Hoek, DVM, PhD, Royal Canin S.A., Centre de Recherche, Aimargues, France; e-mail: ivanhoek@royal-canin.fr.

Publication History

  1. Issue published online: 1 SEP 2009
  2. Article first published online: 11 AUG 2009
  3. Submitted August 14, 2008; Revised May 9, 2009; Accepted June 23, 2009.

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Keywords:

  • Cats;
  • Thyroid;
  • Tubular function;
  • Urinary marker

Background: Retinol-binding protein (RBP) is suggested as a clinically useful marker of renal function in cats.

Hypothesis: Serum and urinary RBP concentrations in hyperthyroid (HT) cats differ from those in healthy (H) cats; radioiodine (131I) treatment influences serum and urinary RBP concentrations in HT cats.

Animals: Ten HT and 8 H cats.

Methods: RBP concentration was evaluated in feline serum and urine samples from a prospective study.

Results: There was a significant (P= .003) difference in the urinary RBP/creatinine (uRBP/c) ratios of H (−) and untreated HT (1.4 ± 1.5 × 10−2 μg/mg) cats. Serum total thyroxine concentration (1.8 ± 1.9 μg/dL, 24 weeks) and uRBP/c (0.6 ± 1.0 × 10−2 μg/mg, 24 weeks) decreased significantly (P < .001) in HT cats at all time points after treatment with 131I, and these variables were significantly correlated with one another (r= 0.42, P= .007). Serum RBP concentrations from HT cats (199 ± 86 μg/L) did not differ significantly (P= .98) from those of H cats (174 ± 60) and did not change after treatment with 131I (182 ± 124 μg/L, P= .80).

Conclusion and Clinical Importance: The presence of urinary RBP in HT cats is a potential marker of tubular dysfunction that is correlated to thyroid status, although it is independent of circulating RBP concentrations. The decreased uRBP/c combined with the absence of changes in serum RBP after treatment suggests that the suspected tubular dysfunction was partly reversible with treatment of 131I.

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