• Open Access

Antithrombotic Effect of Enoxaparin in Clinically Healthy Cats: A Venous Stasis Model

Authors


  • The work described here was performed at Purdue University. Results were presented in poster form at the 2008 ACVIM Forum.

Corresponding author: D.F. Hogan, School of Veterinary Medicine, Purdue University, VCS – Lynn Hall, 625 Harrison Street, West Lafayette, IN 47907-2026; e-mail: hogandf@purdue.edu.

Abstract

Background: Systemic arterial thromboembolic events are a serious complication of cardiac disease in cats.

Objectives: To determine if enoxaparin induces an antithrombotic effect in cats at a dosage of 1 mg/kg SC q12h and if this antithrombotic effect is predicted by anti-Xa activity.

Animals: Fourteen clinically healthy cats were divided into 3 groups: control (4 cats), treated and assessed at 4 hours (5 cats), and treated and assessed at 12 hours (5 cats).

Methods: A venous stasis model was used and the extent of thrombus formation estimated by measuring thrombus weight and accretion of 125I-fibrinogen. Plasma anti-Xa activity was measured in treated cats.

Results: There was a significant reduction in thrombus formation in the 4 h group compared with control (median weight, 0.000 versus 0.565 mg/mm, P < .01; median %125I-fibrinogen accretion, 0.0 versus 42.0%, P < .01). There was a reduction in thrombus formation in the 12 h group (median weight, 0.006 mg/mm, P= .09; median %125I-fibrinogen accretion, 3.83%, P= .09) but this reduction was not significant. The median percent thrombus inhibition for treated cats was 100.0% at 4 hours and 91.4% at 12 hours. Plasma anti-Xa activity was not significantly correlated with thrombus formation.

Conclusions and Clinical Importance: This pilot study demonstrates that enoxaparin, when administered at a dosage of 1 mg/kg SC q12h, produces an antithrombotic effect in a venous statsis model in clinically healthy cats. Furthermore, this study demonstrates that anti-Xa activity is a poor predictor of enoxaparin's antithrombotic effect.

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