Cardiac Troponin I Is Associated with Severity of Myxomatous Mitral Valve Disease, Age, and C-Reactive Protein in Dogs

  1. I. Ljungvall1,
  2. K. Höglund2,
  3. A. Tidholm3,
  4. L.H. Olsen4,
  5. M. Borgarelli5,
  6. P. Venge6,
  7. J. Häggström1

Article first published online: 30 NOV 2009

DOI: 10.1111/j.1939-1676.2009.0428.x

Issue

Journal of Veterinary Internal Medicine

Journal of Veterinary Internal Medicine

Volume 24, Issue 1, pages 153–159, January/February 2010

Additional Information

How to Cite

Ljungvall, I., Höglund, K., Tidholm, A., Olsen, L.H., Borgarelli, M., Venge, P. and Häggström, J. (2010), Cardiac Troponin I Is Associated with Severity of Myxomatous Mitral Valve Disease, Age, and C-Reactive Protein in Dogs. Journal of Veterinary Internal Medicine, 24: 153–159. doi: 10.1111/j.1939-1676.2009.0428.x

Author Information

  1. 1

    Departments of Clinical Sciences, University of Agricultural Sciences, Uppsala, Sweden

  2. 2

    Anatomy, Physiology and Biochemistry, University of Agricultural Sciences, Uppsala, Sweden

  3. 3

    Albano Animal Hospital, Stockholm, Sweden

  4. 4

    Department of Basic Animal and Veterinary Sciences, University of Copenhagen, Fredriksberg, Denmark

  5. 5

    Department of Clinical Sciences, Kansas State University, College of Veterinary Medicine, Manhattan KS

  6. 6

    Department of Clinical Chemistry, The University of Uppsala, Uppsala, Sweden.

*Corresponding author: Dr I. Ljungvall, Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Sciences, The Swedish University of Agricultural Sciences, P.O. Box 7054, 75007 Uppsala, Sweden; e-mail: ingrid.ljungvall@kv.slu.se.

  1. Oral abstract presented at the American College of Veterinary Internal Medicine Forum, Montreal, Canada, June 2009.

  2. The study was performed at the Faculty of Veterinary Medicine and Animal Sciences in Uppsala.

Publication History

  1. Issue published online: 4 JAN 2010
  2. Article first published online: 30 NOV 2009
  3. Submitted May 20, 2009; Revised September 21, 2009; Accepted October 12, 2009.

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Keywords:

  • Cardiology;
  • Echocardiography;
  • Heart failure;
  • Monitoring;
  • Valvular disease

Background: Concentrations of cardiac troponin I (cTnI) and C-reactive protein (CRP) might be associated with cardiac remodeling in dogs with myxomatous mitral valve disease (MMVD). Age- and sex-dependent variations in cTnI concentration have been described.

Objective: To investigate whether plasma concentrations of cTnI and CRP are associated with severity of MMVD, and investigate potential associations of dog characteristics on cTnI and CRP concentrations.

Animals: Eighty-one client-owned dogs with MMVD of varying severity.

Methods: Dogs were prospectively recruited for the study. Dogs were classified according to severity of MMVD. Plasma cTnI was analyzed by a high sensitivity cTnI assay with a lower limit of detection of 0.001 ng/mL, and plasma CRP was analyzed by a canine-specific CRP ELISA.

Results: Higher cTnI concentrations were detected in dogs with moderate (0.014 [interquartile range 0.008–0.029] ng/mL, P= .0011) and severe (0.043 [0.031–0.087] ng/mL, P < .0001) MMVD, compared with healthy dogs (0.001 [0.001–0.004] ng/mL). Dogs with severe MMVD also had higher cTnI concentrations than dogs with mild (0.003 [0.001–0.024] ng/mL, P < .0001) and moderate (P= .0019) MMVD. There were significant associations of age, CRP, heart rate, and left ventricular end-diastolic diameter, on cTnI concentration C-reactive protein did not differ among severity groups, but was significantly associated with cTnI, breed, and systolic blood pressure on CRP concentration.

Conclusions and Clinical Importance: Analysis of cTnI concentration has potential to increase knowledge of overall cardiac remodeling in dogs with MMVD. However, effect of age on cTnI needs consideration when assessing cTnI.

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