This paper was presented in part at the 2007 meeting of the American College of Veterinary Radiology.
Ultrasonographic Evaluation of the Muscularis Propria in Cats with Diffuse Small Intestinal Lymphoma or Inflammatory Bowel Disease
Article first published online: 19 JAN 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 24, Issue 2, pages 289–292, March/April 2010
How to Cite
Zwingenberger, A. L., Marks, S. L., Baker, T. W. and Moore, P. F. (2010), Ultrasonographic Evaluation of the Muscularis Propria in Cats with Diffuse Small Intestinal Lymphoma or Inflammatory Bowel Disease. Journal of Veterinary Internal Medicine, 24: 289–292. doi: 10.1111/j.1939-1676.2009.0457.x
- Issue published online: 1 MAR 2010
- Article first published online: 19 JAN 2010
- Submitted June 30, 2009; Revised October 14, 2009; Accepted November 18, 2009.
- Anatomy and pathology;
- Oncology diagnosis
Background: An ultrasonographic pattern of thickened muscularis propria in the small intestine and lymphadenopathy have been associated with gastrointestinal lymphoma and inflammatory bowel disease (IBD) in cats.
Objectives: To investigate the association of these imaging biomarkers with IBD and lymphoma in cats.
Animals: One hundred and forty-two cats with a histologic diagnosis of normal small intestine (SI) (n = 56), lymphoma (n = 62), or IBD (n = 24).
Methods: Retrospective case review. Pathology records from 1998–2006 were searched for cats with a diagnosis of normal, IBD, or lymphoma, an ultrasonographic examination <28 days before surgery, and without ultrasonographic evidence of a mass. Multinomial regression analysis was used to determine the association of imaging biomarkers with disease status.
Results: Cats with thickening of the muscularis propria detected by ultrasonographic examination were more likely to have lymphoma compared with normal SI cats (odds ratio [OR] = 4.0, 95% confidence interval [95% CI] 1.2–13.1, P= .021) and those with IBD (OR = 18.8, 95% CI 2.2–162.7, P= .008). Histologic samples of cats with muscularis propria thickening were more likely to have disease infiltrates in both the mucosal and submucosal layers (OR = 8.1, 95% CI 1.7–38.4, P= .008) than cats with normal SI. Cats with ultrasonographic evidence of lymphadenopathy were more likely to have a diagnosis of lymphoma (OR = 44.9, 95% CI 5.1–393.0, P= .001) or IBD (OR = 10.8, 95% CI 1.1–106.3, P= .041) than normal SI. Fifty-six of 62 cats had confirmed or presumptive diagnosis of diffuse T-cell lymphoma.
Conclusions and Clinical Relevance: Older cats with muscularis layer thickening are more likely to have T-cell lymphoma than IBD. The ultrasonographic pattern is associated with histologic infiltrates in the mucosal and submucosal layers of small intestine. Lymphadenopathy is associated with lymphoma or IBD.