Parts of this study have been presented previously at the ECVIM meeting 2009 in Porto, Portugal.
Prevalence of Dilated Cardiomyopathy in Doberman Pinschers in Various Age Groups
Article first published online: 23 FEB 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 24, Issue 3, pages 533–538, May/June 2010
How to Cite
Wess, G., Schulze, A., Butz, V., Simak, J., Killich, M., Keller, L.J.M., Maeurer, J. and Hartmann, K. (2010), Prevalence of Dilated Cardiomyopathy in Doberman Pinschers in Various Age Groups. Journal of Veterinary Internal Medicine, 24: 533–538. doi: 10.1111/j.1939-1676.2010.0479.x
- Issue published online: 7 MAY 2010
- Article first published online: 23 FEB 2010
- Submitted September 21, 2009; Revised December 18, 2009; Accepted January 15, 2010.
- Congestive heart failure;
- Dilated cardiomyopathy;
- Sudden death
Background: Dilated cardiomyopathy (DCM) in Doberman Pinschers is an autosomal dominant inherited disease. The prevalence of DCM in Doberman Pinschers of various age groups in Europe is currently unknown, but this information would be important to develop recommendations for screening programs.
Objectives: To evaluate the prevalence of cardiomyopathy in various age groups of Dobermans.
Animals: Seven hundred and seventy-five examinations in 412 Doberman Pinschers.
Methods: Dogs were included in a prospective longitudinal cohort study. Each examination included echocardiography and 24-hour ECG (Holter) examination. A cut-off value of >100 ventricular premature contractions (VPCs) per 24 hours on Holter examination or abnormal echocardiography was considered diagnostic for cardiomyopathy. The cumulative prevalence included all dogs with DCM and healthy dogs >7 years of age.
Results: DCM prevalence in various age groups was as follows: age group 1 (1 to <2 years) 3.3%, age group 2 (2 to <4 years) 9.9%, age group 3 (4 to <6 years) 12.5%, age group 4 (6 to <8 years) 43.6%, and age group 5 (>8 years) 44.1%. The cumulative prevalence of Doberman Pinscher cardiomyopathy was 58.2%. There was an equal sex distribution, but male dogs showed earlier echocardiographic changes than did female dogs, which had significantly more VPCs.
Conclusions and Clinical Importance: The prevalence of Doberman cardiomyopathy is very high in Europe. Disease manifestation and progression are different between male and female dogs. Yearly screening for DCM by Holter examination and echocardiography is recommended, starting at 2 years of age.