This study was performed at the Faculty of Veterinary Medicine of the University of Liège, Belgium. Part of the content of this paper has been presented in posters session at the 23rd World Buiatrics Congress, July 11–16, 2004, Québec, Canada.
Descriptive Study of 32 Cases of Doxycycline-Overdosed Calves
Article first published online: 29 JUL 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 24, Issue 5, pages 1203–1210, September/October 2010
How to Cite
Brihoum, M., Amory, H., Desmecht, D., Cassart, D., Deleuze, S. and Rollin, F. (2010), Descriptive Study of 32 Cases of Doxycycline-Overdosed Calves. Journal of Veterinary Internal Medicine, 24: 1203–1210. doi: 10.1111/j.1939-1676.2010.0560.x
- Issue published online: 2 SEP 2010
- Article first published online: 29 JUL 2010
- Submitted September 2, 2009; Revised April 24, 2010; Accepted May 21, 2010.
Background: Reports of doxycycline-induced toxicity are limited despite common use of this antibiotic to treat infectious respiratory disorders in calves.
Objective: To describe previously unreported kidney lesions and diagnostic test results in doxycycline-overdosed calves and to compare these results with other findings reported previously.
Animals: Thirty-two calves that presented with adverse effects after receiving high doses of doxycycline as a treatment for mild respiratory disorders.
Method: Retrospective review of medical records.
Results: Clinical examination identified mainly lethargy, dyspnea, cough, tongue paresia or paralysis associated with dysphagia and sialorrhea, tachycardia, tachypnea, and signs of myopathy. Blood analysis indicated increases in creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and sorbitol dehydrogenase activities and increased serum creatinine and urea concentrations. ECG recordings and Doppler echocardiography examination identified ventricular premature beats and a decrease in left ventricular global and systolic function, respectively. Necropsy and histopathology disclosed necrosis of the myocardium, tongue, and some striated muscles, acute renal tubular necrosis, and fatty degeneration or congestion of the liver.
Conclusions: Most of these findings corroborate previous observations made in doxycycline-overdosed calves, and further suggest myocardial and striated muscular toxicity as well as renal toxicity in doxycycline-overdosed calves.