Animals were recruited from 27 privately owned veterinary hospitals in the United States, and analyses were carried out at Hill's Pet Nutrition Inc, Topeka, KS.
Dose-Titration Effects of Fish Oil in Osteoarthritic Dogs
Article first published online: 12 AUG 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 24, Issue 5, pages 1020–1026, September/October 2010
How to Cite
Fritsch, D., Allen, T.A., Dodd, C.E., Jewell, D.E., Sixby, K.A., Leventhal, P.S. and Hahn, K.A. (2010), Dose-Titration Effects of Fish Oil in Osteoarthritic Dogs. Journal of Veterinary Internal Medicine, 24: 1020–1026. doi: 10.1111/j.1939-1676.2010.0572.x
- Issue published online: 2 SEP 2010
- Article first published online: 12 AUG 2010
- Submitted September 17, 2009; Revised March 14, 2010; Accepted June 21, 2010.
Vol. 25, Issue 1, 167, Article first published online: 11 JAN 2011
- fatty acid;
Background: Food supplemented with fish oil improves clinical signs and weight bearing in dogs with osteoarthritis (OA).
Objective: Determine whether increasing the amount of fish oil in food provides additional symptomatic improvements in OA.
Animals: One hundred and seventy-seven client-owned dogs with stable chronic OA of the hip or stifle.
Methods: Prospective, randomized clinical trial using pet dogs. Dogs were randomly assigned to receive the baseline therapeutic food (0.8% eicosopentanoic acid [EPA] + docosahexaenoic acid [DHA]) or experimental foods containing approximately 2- and 3-fold higher EPA+DHA concentrations. Both veterinarians and owners were blinded as to which food the dog received. On days 0, 21, 45, and 90, serum fatty acid concentrations were measured and veterinarians assessed the severity of 5 clinical signs of OA. At the end of the study (day 90), veterinarians scored overall arthritic condition and progression of arthritis based on their clinical signs and an owner interview.
Results: Serum concentrations of EPA and DHA rose in parallel with food concentrations. For 2 of 5 clinical signs (lameness and weight bearing) and for overall arthritic condition and progression of arthritis, there was a significant improvement between the baseline and 3X EPA+DHA foods (P=.04, .03, .001, .0008, respectively) but not between the baseline and the 2X EPA+DHA foods.
Conclusions and Clinical Importance: Increasing the amount of fish oil beyond that in the baseline food results in dose-dependent increases in serum EPA and DHA concentrations and modest improvements in the clinical signs of OA in pet dogs.