The Influence of High-Intensity Moderate Duration Exercise on Cardiac Troponin I and C-Reactive Protein in Sled Dogs
Article first published online: 14 SEP 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 24, Issue 6, pages 1388–1392, November/December 2010
How to Cite
Wakshlag, J.J., Kraus, M.S., Gelzer, A.R., Downey, R.L. and Vacchani, P. (2010), The Influence of High-Intensity Moderate Duration Exercise on Cardiac Troponin I and C-Reactive Protein in Sled Dogs. Journal of Veterinary Internal Medicine, 24: 1388–1392. doi: 10.1111/j.1939-1676.2010.0594.x
- Issue published online: 3 NOV 2010
- Article first published online: 14 SEP 2010
- Submitted March 24, 2010; Revised July 6, 2010; Accepted July 30, 2010.
Background: C-reactive protein (CRP) and cardiac troponin I (cTnI) are biomarkers of systemic inflammation and cardiac damage, respectively.
Objective: To investigate the effects of short-duration high-intensity exercise on plasma cTnI and serum CRP concentrations in sprint racing sled dogs.
Animals: Twenty-two Alaskan sled dogs of 2 different teams participating in a 2-day racing event.
Methods: In this prospective field study, cephalic venipuncture was performed on all dogs before racing and immediately after racing on 2 consecutive days. Plasma cTnI and serum CRP concentrations were evaluated at each time point.
Results: There was a mild, significant rise (P < .01) in median cTnI concentrations from resting (0.02 ng/mL; 0.0–0.12 ng/mL) on both days after racing (day 1 = 0.06, 0.02–0.2 ng/mL; day 2 = 0.07, 0.02–0.21 ng/mL). Serum CRP concentrations showed a mild significant increase (P < .01) on day 2 after racing mean (9.2 ± 4.6 μg/mL) as compared with resting (6.5 + 4.3 μg/mL) and day 1 after racing (5.0 + 2.9 μg/mL). Neither cTnI or CRP concentrations exceeded the upper reference range for healthy dogs.
Conclusions and Clinical Relevance: Strenuous exercise of short duration did not result in cTnI concentrations above the reference range for healthy dogs. Although increased after 2 days of short-duration strenuous exercise, CRP did not reach concentrations suggestive of inflammation, as reported previously in the endurance sled dogs. Therefore, we surmise that moderate exercise does not present a confounding variable in the interpretation of cTnI and CRP concentrations in normal dogs.