This work was previously presented as an abstract at the 19th Congress of the European College of Veterinary Internal Medicine—Companion Animals, Porto, Portugal, September 2009.
Pulmonary Blood Volume in Mitral Regurgitation in Cavalier King Charles Spaniels
Article first published online: 19 OCT 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 24, Issue 6, pages 1393–1399, November/December 2010
How to Cite
Eriksson, A., Hansson, K., Häggström, J., Järvinen, A.-K. and Lord, P. (2010), Pulmonary Blood Volume in Mitral Regurgitation in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine, 24: 1393–1399. doi: 10.1111/j.1939-1676.2010.0619.x
- Issue published online: 3 NOV 2010
- Article first published online: 19 OCT 2010
- Submitted April 4, 2010; Revised August 8, 2010; Accepted September 9, 2010.
- Heart failure;
Background: Pulmonary edema and venous congestion are well-recognized signs of congestive heart failure (CHF) in advanced canine chronic mitral regurgitation (MR). However, little is known about pulmonary blood volume (PBV), blood pulmonary transit time (PTT), and the regulation of these.
Objectives: To measure and evaluate the relationships of PBV, forward stroke volume (FSV), and heart rate normalized blood pulmonary transit time (nPTT) in healthy dogs and dogs with MR.
Animals: Thirty-three Cavalier King Charles Spaniels; 11 healthy, 4 in modified New York Heart Association (NYHA) class I, 11 in class II, and 7 in CHF.
Methods: Heart rate normalized PTTs were measured by radionuclide angiocardiography. Left ventricular end diastolic and systolic diameter, left atrial/aortic root ratio, and FSV were measured by echocardiography. PBV and pulmonary blood volume index (PBVI) were calculated by established formulas.
Results: PBVI was 308 ± 56 (mean ± SD) mL/m2 for healthy dogs, 287 ± 51 mL/m2 in NYHA class I, 360 ± 66 mL/m2 in Class II, and 623 ± 232 mL/m2 in CHF (P= .0008). Heart rate normalized PTT, not FSV, was a predictor of PBV (r= 0.92 and 0.02, respectively).
Conclusions and Clinical Importance: Increased PBV, not decreased FSV, is the main cause of increased nPTT in MR. Increased nPTT can be used as an indicator of abnormal cardiopulmonary function in dogs with MR.