The study was done at the Clinic for Small Animal Internal Medicine and Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Remission of Diabetes Mellitus in Cats Cannot be Predicted by the Arginine Stimulation Test
Article first published online: 10 DEC 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 1, pages 83–89, January/February 2011
How to Cite
Tschuor, F., Zini, E., Schellenberg, S., Wenger, M., Kaufmann, K., Furrer, D., Lutz, T.A. and Reusch, C.E. (2011), Remission of Diabetes Mellitus in Cats Cannot be Predicted by the Arginine Stimulation Test. Journal of Veterinary Internal Medicine, 25: 83–89. doi: 10.1111/j.1939-1676.2010.0649.x
- Issue published online: 11 JAN 2011
- Article first published online: 10 DEC 2010
- Submitted April 15, 2010; Revised September 30, 2010; Accepted October 15, 2010.
Background: Cats with diabetes mellitus frequently achieve clinical remission, suggesting residual β-cell function. Responsiveness of β-cells to arginine persists the longest during diabetes progression, making the intravenous arginine stimulation test (IVAST) a useful tool to assess residual insulin and glucagon secretion.
Hypothesis: Diabetic cats with and without remission will have different arginine-induced insulin or glucagon response.
Animals: Seventeen cats with diabetes, 7 healthy cats.
Methods: Blood samples collected on admission and during subsequent IVAST. Glucose, insulin, and glucagon were measured. Response to IVAST was assessed by calculating the insulin and glucagon area under the curve (AUC) and the AUC glucagon-to-insulin ratio. Diabetic cats were treated with insulin and were followed for 18 weeks. Remission was defined as normoglycemia and disappearance of clinical signs of diabetes for ≥4 weeks, without requiring insulin.
Results: Seven diabetic cats (41%) achieved remission. On admission, blood glucose concentration was significantly lower in cats with remission (median, 389 mg/dL; range, 342–536 mg/dL) than in those without remission (median, 506 mg/dL; range, 266–738 mg/dL). After IVAST, diabetic cats with remission had higher AUC glucagon-to-insulin ratios (median, 61; range, 34–852) than did cats without remission (median, 26; range, 20–498); glucose, insulin, and glucagon AUCs were not different. Diabetic cats had lower insulin AUC than did healthy cats but comparable glucagon AUC.
Conclusions and Clinical Importance: Diabetic cats with and without remission have similar arginine-stimulated insulin secretion on admission. Although cats with remission had lower blood glucose concentrations and higher AUC glucagon-to-insulin ratios, large overlap between groups prevents use of these parameters in clinical practice.