This work was done at the College of Veterinary Medicine of North Carolina State University. This work was presented as an oral scientific abstract at the 2010 ACVIM Forum in Anaheim, California.
Efficacy of Oral Famotidine and 2 Omeprazole Formulations for the Control of Intragastric pH in Dogs
Article first published online: 8 DEC 2010
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 1, pages 47–54, January/February 2011
How to Cite
Tolbert, K., Bissett, S., King, A., Davidson, G., Papich, M., Peters, E. and Degernes, L. (2011), Efficacy of Oral Famotidine and 2 Omeprazole Formulations for the Control of Intragastric pH in Dogs. Journal of Veterinary Internal Medicine, 25: 47–54. doi: 10.1111/j.1939-1676.2010.0651.x
- Issue published online: 11 JAN 2011
- Article first published online: 8 DEC 2010
- Submitted May 26, 2010; Revised August 20, 2010; Accepted October 18, 2010.
- Acid disorders;
Background: Little is known about the efficacy of commonly used acid suppressants on intragastric pH in dogs.
Objective: To compare the effect of oral famotidine, 2 formulations of omeprazole, and placebo on intragastric pH in dogs with a catheter-free, continuous pH monitoring system.
Animals: Six healthy adult mixed-breed colony dogs.
Methods: Utilizing a randomized, 4-way cross over, open-label study, dogs were administered famotidine PO (1.0–1.3 mg/kg q12h), omeprazole tablet (1.5–2.6 mg/kg q24h), omeprazole reformulated paste (RP) (Gastrogard, 1.5–2.6 mg/kg q24h), and placebo for 7 days followed by a 10-day washout period. Radiotelemetric pH capsules were placed with gastroscopy assistance to continuously record intragastric pH for 4 days (days 4–7 of dosing). The percentage of time that intragastric pH was ≥3 and ≥4 was compared among treatment groups using repeated measures of analysis of variance. Tukey's Studentized range test was used to determine which groups were different with α= 0.05.
Results: Mean ± SD percent time intragastric pH was ≥3 and ≥4 was 22 ± 8% and 14 ± 6% for famotidine, 63 ± 14% and 52 ± 17% for omeprazole tablet, 54 ± 17% and 44 ± 18% for omeprazole RP, and 6 ± 6% and 5 ± 5% for placebo. Both omeprazole formulations significantly increased intragastric pH compared with famotidine and placebo, but omeprazole tablet and RP was not significantly different from each other.
Conclusion: Oral omeprazole tablet and RP provide superior gastric acid suppression to famotidine, and should therefore be considered more effective for the treatment of acid related disorders in dogs.