The literature review was undertaken at Tufts Cummings School of Veterinary Medicine. No primary research was conducted. The summarized data have not appeared at any meeting.
Portal Hypertension: Pathophysiology, Diagnosis, and Treatment
Article first published online: 7 MAR 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 2, pages 169–186, March/April 2011
How to Cite
Buob, S., Johnston, A.N. and Webster, C.R.L. (2011), Portal Hypertension: Pathophysiology, Diagnosis, and Treatment. Journal of Veterinary Internal Medicine, 25: 169–186. doi: 10.1111/j.1939-1676.2011.00691.x
- Issue published online: 7 MAR 2011
- Article first published online: 7 MAR 2011
- Submitted August 2, 2010; Revised October 27, 2010; Accepted January 6, 2011.
- Hepatic disease;
- Portosystemic shunts
Portal hypertension (PH) is the result of increased vascular resistance in the portal circulation, increased portal venous blood flow, or both. In veterinary medicine, where portal pressure is seldom measured directly, the diagnosis of PH often is inferred from identification of associated complications including multiple acquired portosystemic shunts, ascites, and hepatic encephalopathy. Likewise, treatment of PH primarily is aimed at controlling these complications. The goal of this review is to provide an update on the pathophysiology, diagnosis, and treatment of PH. The review draws from information in the veterinary hepatology literature, reviews, and consensus statements in human hepatology and the literature on experimental models of PH.