• Open Access

Evaluation of Predictors for the Diagnosis of Hyperthyroidism in Cats

Authors


  • The data have previously been published in abstract form. Wakeling J, Elliott J, Syme HM. Subclinical hyperthyroidism in cats. Endo Abstr 2007;13:315; and Wakeling J, Elliott J, Syme HM. TSH measurement in cats: a prospective study J Vet Intern Med 22(3):725.

Corresponding author: J. Wakeling, Capilano Pet Hospital, 2580 Capilano Road, North Vancouver, BC, V7R 4H2, Canada; e-mail: jenniferwakeling@gmail.com.

Abstract

Background:

In humans, subclinical hyperthyroidism is diagnosed when serum thyroid hormone concentrations are within the reference range but thyroid stimulating hormone (TSH) concentration is subnormal. In a previous study, a higher prevalence of thyroid nodular disease was found in euthyroid geriatric cats with undetectable TSH (<0.03 ng/mL) compared to those with detectable TSH concentrations, suggesting subclinical hyperthyroidism might also exist in cats.

Hypothesis:

Euthyroid cats with undetectable TSH concentrations have subclinical hyperthyroidism and may subsequently develop overt signs of hyperthyroidism.

Animals:

One-hundred four client-owned cats.

Methods:

In this prospective cohort study, euthyroid geriatric (≥9 years) cats were recruited during routine health checks. Plasma biochemistry was performed at baseline and every 6 months thereafter. Total thyroxine and TSH concentrations were determined annually. Short-term follow-up data (within 14 months of recruitment) were used to detect variables at entry that were predictive of the diagnosis of hyperthyroidism, using univariable analysis followed by multivariable logistic regression analysis. Log rank analysis was used to test the association of initial TSH concentration with diagnosis of hyperthyroidism during the total available follow-up.

Results and Conclusions:

Median (range) follow-up was 26 (0–54) months and annual incidence of hyperthyroidism during the study was 7.4%. Cats that became hyperthyroid within 14 months had higher ALKP activity (P = 0.02) and higher prevalence of goiter (P = .03) at baseline than controls. Cats with undetectable TSH at baseline (29/104; 28%) were significantly (P < .001) more likely to be diagnosed with hyperthyroidism. However, not all cats with undetectable TSH became hyperthyroid during the study.

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