This work was conducted in Department of Small Animal Clinical Sciences, University of Copenhagen, Dyrlægevej 16, DK-1870 Frederiksberg C.
Epilepsy in the Petit Basset Griffon Vendeen: Prevalence, Semiology, and Clinical Phenotype
Version of Record online: 13 SEP 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 6, pages 1372–1378, November-December 2011
How to Cite
Gulløv, C.H., Toft, N., Baadsager, M.M.N. and Berendt, M. (2011), Epilepsy in the Petit Basset Griffon Vendeen: Prevalence, Semiology, and Clinical Phenotype. Journal of Veterinary Internal Medicine, 25: 1372–1378. doi: 10.1111/j.1939-1676.2011.00791.x
While the study was still ongoing, selected preliminary results were presented by poster including an abstract “Genetic Epilepsy in the Petit Basset Griffon Vendeen” at the 4th Share Symposium at the University of Copenhagen.
- Issue online: 16 NOV 2011
- Version of Record online: 13 SEP 2011
- Manuscript Accepted: 26 JUL 2011
- Manuscript Revised: 23 JUN 2011
- Manuscript Received: 28 APR 2011
- Danish Kennel Club
Epilepsy with a genetic background is increasingly being identified. In certain dog breeds, epilepsy occurs with a higher prevalence than the estimate of 1–2% reported in the general dog population.
The Petit Basset Griffon Vendeen (PBGV) experiences an increased occurrence of epilepsy compared to the general dog population.
The target population consisted of all 876 PBGV dogs registered in the Danish Kennel Club from January 1, 1999 to December 31, 2008. The study population included 820 dogs that met the inclusion criteria.
A population study was conducted to estimate the prevalence of epilepsy in the Danish PBGV population. A mailed questionnaire was used to detect possible signs of epilepsy. The information was subsequently validated by telephone interviews of positive and possible positive responders and a negative responder control group, using an extensive questionnaire developed to detect epilepsy. Dogs evaluated as epilepsy positive after the telephone interview were offered a clinical investigation.
The prevalence of epilepsy was estimated to be 8.9% (42/471) in the PBGV population. Average age of onset was 26.3 months. Sex and mode of response did not affect the prevalence, but a strong litter effect was seen. Among euthanized dogs, epilepsy was the predominant cause (6/45 = 13.3%).
Conclusion and Clinical Importance
Petit Basset Griffon Vendeen dogs experience an increased risk of epilepsy characterized by a relatively early onset and dominated by focal seizures with and without secondary generalization. With an estimated prevalence of 8.9% and substantial clustering within litters, a genetic factor associated with epilepsy is suspected.