• Open Access

Canine Cutaneous Perivascular Wall Tumors at First Presentation: Clinical Behavior and Prognostic Factors in 55 Cases

Authors


  • This work was performed in the Faculty of Veterinary Medicine of Milan. This study has been presented as resident abstract at the Annual Congress of the European Society of Veterinary Oncology in Glasgow, Scotland, 24th–26th March 2011.

Corresponding author: D. Stefanello, DVM, PhD, Dipartimento di Scienze Cliniche Veterinarie, Università degli Studi di Milano, Via G. Ponzio 7, 20133 Milan, Italy; e-mail: damiano.stefanello@unimi.it.

Abstract

Background

Canine cutaneous perivascular wall tumors (c-PWT) are soft tissue sarcomas recently identified when hemangiopericytomas were reclassified. No previous clinical data are available for c-PWT.

Hypothesis/Objectives

To define the clinical behavior and prognostic role of clinical and pathological variables in a homogeneous population of c-PWT.

Animals

Fifty-five c-PWT in 53 client-owned dogs at first presentation undergoing surgery.

Methods

Retrospective case series. The endpoint was the relapse of tumor (local and/or distant). The prognostic values of clinical (age, sex, weight, site and tumor size, adjuvant therapy) and pathological (status of surgical margins, histological grade, mitosis, percentage of tumor necrosis) variables were investigated by univariate and bivariate analyses (P < .05). The pattern of associations between variables was explored by multivariate correspondence analysis (MCA).

Results

Twelve dogs had a relapse. Ten dogs had local recurrence, 1 had metastatic disease, and 1 had both. The estimated probability of local recurrence was 0.02, 0.08, 0.20, and 0.24 at 6 months, 1, 2, and 3 years, respectively. Size of the tumor was a significant prognostic factor while status of margins had only a clinically relevant hazard ratio. In MCA evaluation, young age, tumor size (< 5 cm), grade I, and location in the extremities were associated. Association was also observed for older age, tumor size (> 5 cm), grade II, and other location.

Conclusion and Clinical Importance

C-PWT tend to locally recur a long time after surgery. An early diagnosis of c-PWT associated with small tumor size (< 5 cm) and clean surgical margins ensures a good prognosis independently of histological grade.

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