Normal Dogs Treated with Famotidine for 14 days Have Only Transient Increases in Serum Gastrin Concentrations
Article first published online: 1 NOV 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 6, pages 1248–1252, November-December 2011
How to Cite
Mordecai, A., Sellon, R.K. and Mealey, K.L. (2011), Normal Dogs Treated with Famotidine for 14 days Have Only Transient Increases in Serum Gastrin Concentrations. Journal of Veterinary Internal Medicine, 25: 1248–1252. doi: 10.1111/j.1939-1676.2011.00826.x
- Issue published online: 16 NOV 2011
- Article first published online: 1 NOV 2011
- Manuscript Accepted: 19 SEP 2011
- Manuscript Revised: 8 AUG 2011
- Manuscript Received: 26 APR 2011
- H2-receptor antagonist;
- Zollinger-Ellison syndrome;
In people, serum gastrin concentrations increase in response to administration of H2 receptor antagonists, but the effect of famotidine administration on serum gastrin concentrations has not been evaluated in dogs.
To determine if serum gastrin concentrations increase in response to 14 days of famotidine treatment and the time needed to return to baseline after discontinuation of famotidine; define stability of gastrin in samples held at room temperature.
Eleven healthy dogs were included in part A (famotidine treatment) and 7 healthy dogs in Part B (serum gastrin stability). In part A, famotidine (0.5 mg/kg PO q12h) was administered for 14 days. Fasting blood samples were collected on days 0, 3, 7, 11, 14, 16, 18, 20, and 22. In part B, blood was collected after a 12-hour fast. Gastrin concentrations in serum samples held at room temperature for ≤30 minutes after sampling were compared to concentrations in samples held at room temperature for 150 minutes after sampling.
Serum gastrin concentrations increased by day 3 of famotidine administration and returned to baseline concentrations in all dogs by day 14 despite continued famotidine administration. Serum gastrin concentrations were lower (20% mean decrease; P = .0005) in samples held at room temperature for 150 minutes.
Conclusions and Clinical Importance
After 14 days of famotidine administration, clinically healthy dogs have normal serum gastrin concentrations. In a dog with clinical features consistent with gastrinoma, chronic famotidine administration is unlikely to contribute to increases in serum gastrin concentrations.