• Open Access

Renal Resistive Index in 55 Dogs with Degenerative Mitral Valve Disease

Authors

  • V. Chetboul,

    1. Unité de Cardiologie d'Alfort and Centre Hospitalier Universitaire Vétérinaire d'Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort
    2. UMR INSERM U955, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort
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  • T. Daste,

    1. the Université de Toulouse, INP, Ecole Nationale Vétérinaire de Toulouse, UR Clinique, Toulouse
    2. Département des Sciences Cliniques, Toulouse
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  • V. Gouni,

    1. Unité de Cardiologie d'Alfort and Centre Hospitalier Universitaire Vétérinaire d'Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort
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  • D. Concordet,

    1. Université de Toulouse, INPT, Ecole Nationale Vétérinaire de Toulouse, F-31076 Toulouse & INRA, Toulouse
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  • E. Trehiou-Sechi,

    1. Unité de Cardiologie d'Alfort and Centre Hospitalier Universitaire Vétérinaire d'Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort
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  • F. Serres,

    1. Unité de Cardiologie d'Alfort and Centre Hospitalier Universitaire Vétérinaire d'Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort
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  • J.L. Pouchelon,

    1. UMR INSERM U955, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort
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  • C.A. Germain,

    1. Département des Sciences Cliniques, Toulouse
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  • C. Layssol-Lamour,

    1. Département des Sciences Cliniques, Toulouse
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  • H.P. Lefebvre

    Corresponding author
    1. the Université de Toulouse, INP, Ecole Nationale Vétérinaire de Toulouse, UR Clinique, Toulouse
    2. Département des Sciences Cliniques, Toulouse
    • Unité de Cardiologie d'Alfort and Centre Hospitalier Universitaire Vétérinaire d'Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort
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  • Dogs were recruited at the National Veterinary School of Alfort. Plasma assays (except NT-proBNP) and statistical analyses were performed at the National Veterinary School of Toulouse.
  • Abstract presented at the 2011 ACVIM Forum, Denver, CO.

Corresponding author: H.P. Lefebvre, Université de Toulouse, INP, UR Clinique, Ecole Nationale Vétérinaire de Toulouse, 23 chemin des Capelles, BP 87614, 31076 Toulouse cedex 03, France; e-mail: h.lefebvre@envt.fr.

Abstract

Background

Azotemia occurs frequently in dogs with degenerative mitral valve disease (DMVD). It could indicate changes in renal hemodynamics.

Hypothesis/Objectives

To assess the renal resistive index (RI) in dogs with DMVD, and the statistical link between heart failure class, azotemia, echo-Doppler parameters, several plasma variables, and RI.

Animals

Fifty-five dogs with naturally occurring DVMD were used (ISACHC class 1 [n = 28], 2 [n = 19], and 3 [n = 8]).

Methods

Observational, blinded study, performed under standardized conditions. Physical examination, renal ultrasonography, and echo-Doppler examinations were performed in awake dogs. The RI of the renal, interlobar, and arcuate arteries were measured. Plasma creatinine, urea, and N-terminal pro-B-type natriuretic peptide concentrations (NT-proBNP) were determined. Statistical links between variables and RI were tested by means of a general linear model.

Results

Although the RI of renal and arcuate arteries were unaffected by ISACHC class, the left interlobar RI increased (P < .001) from 0.62 ± 0.05 (mean ± SD) in class 1 to 0.76 ± 0.08 in class 3. It was also higher (P < .001) in azotemic (0.74 ± 0.08) than in non-azotemic (0.62 ± 0.05) dogs. Similar findings were observed for right interlobar RI. Univariate analysis showed a positive statistical link between NT-proBNP (P = .002), urea (P < .001), creatinine (P = .002), urea-to-creatinine ratio (P < .001), left atrium-to-aorta ratio (P < .001), regurgitation fraction (P < .001), systolic pulmonary arterial pressure (P < .001), shortening fraction (P = .035), and RI.

Conclusion and Clinical Importance

In dogs with DMVD, interlobar RI increases with heart failure severity and azotemia but a cause and effect relationship remains to be established.

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